Pheripheral benzodiazepine receptors in lymphocytes of essential hypertensive patients

G. Bianchi, A. Frattola, G. Mancia, D. Passoni, R. Tortorella, C. Ferrarese

Research output: Contribution to journalArticlepeer-review

Abstract

Particular psychological traits and abnormal reactivity to stress have been described in hypertensive patients. We investigated modifications of peripheral benzodiazepine receptors (PBR) in mononuclear blood cells of patients with essential hypertension, as possible neurochemical markers of these traits. PBR densities and affinity were evaluated in 10 hypertensive patients and 10 controls. No alteration of receptor density and affinity was observed in our patients, characterized by a normal renin-angiotensin system. PBR do not seem implicated in this type of hypertension, but could be involved in the pathogenesis of high-renin hypertension, as suggested by studies in animal models.

Original languageEnglish
Pages (from-to)307-312
Number of pages6
JournalNeuroendocrinology Letters
Volume17
Issue number4
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

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