TY - JOUR
T1 - Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22
AU - Palumbo, Antonio P.
AU - Boccadoro, Mario
AU - Battaglio, Silvano
AU - Corradini, Paolo
AU - Giovinazzo, Bruna
AU - Avanzi, Giancarlo
AU - Ponzio, Giuseppe
PY - 1989
Y1 - 1989
N2 - We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).
AB - We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).
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U2 - 10.1016/0165-4608(89)90232-X
DO - 10.1016/0165-4608(89)90232-X
M3 - Article
C2 - 2731151
AN - SCOPUS:0024348832
VL - 39
SP - 77
EP - 80
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -