Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22

Antonio P. Palumbo, Mario Boccadoro, Silvano Battaglio, Paolo Corradini, Bruna Giovinazzo, Giancarlo Avanzi, Giuseppe Ponzio

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume39
Issue number1
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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