Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation

Nicla Porciello, Martina Kunkl, Antonella Viola, Loretta Tuosto

Research output: Contribution to journalShort survey

Abstract

Phosphatidylinositol 4,5-biphosphate kinases (PIP5Ks) are critical regulators of T cell activation being the main enzymes involved in the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2). PIP2 is indeed a pivotal regulator of the actin cytoskeleton, thus controlling T cell polarization and migration, stable adhesion to antigen-presenting cells, spatial organization of the immunological synapse, and co-stimulation. Moreover, PIP2 also serves as a precursor for the second messengers inositol triphosphate, diacylglycerol, and phosphatidylinositol 3,4,5-triphosphate, which are essential for the activation of signaling pathways regulating cytokine production, cell cycle progression, survival, metabolism, and differentiation. Here, we discuss the impact of PIP5Ks on several T lymphocyte functions with a specific focus on the role of CD28 co-stimulation in PIP5K compartimentalization and activation.

Original languageEnglish
Article number186
JournalFrontiers in Immunology
Volume7
Issue numberMAY
DOIs
Publication statusPublished - 2016

Keywords

  • Actin cytoskeleton
  • CD28 co-stimulation
  • Metabolism
  • PIP5K
  • T cell signaling

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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