Phospholipase A2 (PLA2) and phenothiazines: Evidence for a correlation in blocking phagocyte function

A. Mazzone, S. Sacchi, R. Degiulio, P. Sacchi, G. Ricevuti

Research output: Contribution to journalArticle

Abstract

We studied some neutrophil functions i.e. chemotaxis, superoxide production and aggregation in 10 normal controls under resting conditions and after incubation with promazine (50-250 μg/ml). We measured concentrations of 6-Keto-Prostaglandin 1α(6KPGF 1α) and Leukotriene C4(LTC4) in the supernatants of neutrophil suspensions after phytohemagglutinin (PHA) induced aggregation. Promazine at all concentrations decreased neutrophil function and LTC4 release.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalHematology Reviews and Communications
Volume2
Issue number2
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Phospholipase A<sub>2</sub> (PLA<sub>2</sub>) and phenothiazines: Evidence for a correlation in blocking phagocyte function'. Together they form a unique fingerprint.

  • Cite this