Phospholipase C δ2 expression characterizes the neoplastic transformation of the human gastric mucosa

Marco Marchisio, Angela Di Baldassarre, Domenico Angelucci, Elisabetta Caramelli, Amelia Cataldi, Sergio Castorina, Adriano Antonucci, Luigina Di Giovannantonio, Cosima Schiavone, Rosa Di Biagio, Mirella Falconi, Giorgio Zauli, Sebastiano Miscia

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Abstract

The expression, cellular distribution, and activity of PIP2-specific phospholipase C (PLC) in healthy human gastric-mucosa cells have been recently studied in our laboratories and a direct evidence for an almost exclusive expression of PLC β isoforms, with the exception of PLC β4, has been provided. These results addressed our attention to possible modification of PLC expression and activity during neoplastic transformation of the human gastric mucosa. In the present article we present results indicating that PLC δ2 is markedly expressed in type II intestinal metaplasia and in the adenocarcinoma whereas traces of other PLC isoforms were sometime detected. Interestingly, we found that type I intestinal metaplasia was in the majority of the cases PLC δ2-negative, but when expressed, this type of metaplasia generally considered as benignant, always evolved toward neoplastic transformation. These results therefore readdress the question of surveillance of the patients with type I intestinal metaplasia and suggest that PLC δ2 expression might be a possible marker of gastric malignant transformation.

Original languageEnglish
Pages (from-to)803-808
Number of pages6
JournalAmerican Journal of Pathology
Volume159
Issue number3
Publication statusPublished - 2001

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Marchisio, M., Di Baldassarre, A., Angelucci, D., Caramelli, E., Cataldi, A., Castorina, S., Antonucci, A., Di Giovannantonio, L., Schiavone, C., Di Biagio, R., Falconi, M., Zauli, G., & Miscia, S. (2001). Phospholipase C δ2 expression characterizes the neoplastic transformation of the human gastric mucosa. American Journal of Pathology, 159(3), 803-808.