Phospholipase C δ2 expression characterizes the neoplastic transformation of the human gastric mucosa

Marco Marchisio, Angela Di Baldassarre, Domenico Angelucci, Elisabetta Caramelli, Amelia Cataldi, Sergio Castorina, Adriano Antonucci, Luigina Di Giovannantonio, Cosima Schiavone, Rosa Di Biagio, Mirella Falconi, Giorgio Zauli, Sebastiano Miscia

Research output: Contribution to journalArticle

Abstract

The expression, cellular distribution, and activity of PIP2-specific phospholipase C (PLC) in healthy human gastric-mucosa cells have been recently studied in our laboratories and a direct evidence for an almost exclusive expression of PLC β isoforms, with the exception of PLC β4, has been provided. These results addressed our attention to possible modification of PLC expression and activity during neoplastic transformation of the human gastric mucosa. In the present article we present results indicating that PLC δ2 is markedly expressed in type II intestinal metaplasia and in the adenocarcinoma whereas traces of other PLC isoforms were sometime detected. Interestingly, we found that type I intestinal metaplasia was in the majority of the cases PLC δ2-negative, but when expressed, this type of metaplasia generally considered as benignant, always evolved toward neoplastic transformation. These results therefore readdress the question of surveillance of the patients with type I intestinal metaplasia and suggest that PLC δ2 expression might be a possible marker of gastric malignant transformation.

Original languageEnglish
Pages (from-to)803-808
Number of pages6
JournalAmerican Journal of Pathology
Volume159
Issue number3
Publication statusPublished - 2001

Fingerprint

Type C Phospholipases
Gastric Mucosa
Metaplasia
Protein Isoforms
Stomach
Adenocarcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Marchisio, M., Di Baldassarre, A., Angelucci, D., Caramelli, E., Cataldi, A., Castorina, S., ... Miscia, S. (2001). Phospholipase C δ2 expression characterizes the neoplastic transformation of the human gastric mucosa. American Journal of Pathology, 159(3), 803-808.

Phospholipase C δ2 expression characterizes the neoplastic transformation of the human gastric mucosa. / Marchisio, Marco; Di Baldassarre, Angela; Angelucci, Domenico; Caramelli, Elisabetta; Cataldi, Amelia; Castorina, Sergio; Antonucci, Adriano; Di Giovannantonio, Luigina; Schiavone, Cosima; Di Biagio, Rosa; Falconi, Mirella; Zauli, Giorgio; Miscia, Sebastiano.

In: American Journal of Pathology, Vol. 159, No. 3, 2001, p. 803-808.

Research output: Contribution to journalArticle

Marchisio, M, Di Baldassarre, A, Angelucci, D, Caramelli, E, Cataldi, A, Castorina, S, Antonucci, A, Di Giovannantonio, L, Schiavone, C, Di Biagio, R, Falconi, M, Zauli, G & Miscia, S 2001, 'Phospholipase C δ2 expression characterizes the neoplastic transformation of the human gastric mucosa', American Journal of Pathology, vol. 159, no. 3, pp. 803-808.
Marchisio M, Di Baldassarre A, Angelucci D, Caramelli E, Cataldi A, Castorina S et al. Phospholipase C δ2 expression characterizes the neoplastic transformation of the human gastric mucosa. American Journal of Pathology. 2001;159(3):803-808.
Marchisio, Marco ; Di Baldassarre, Angela ; Angelucci, Domenico ; Caramelli, Elisabetta ; Cataldi, Amelia ; Castorina, Sergio ; Antonucci, Adriano ; Di Giovannantonio, Luigina ; Schiavone, Cosima ; Di Biagio, Rosa ; Falconi, Mirella ; Zauli, Giorgio ; Miscia, Sebastiano. / Phospholipase C δ2 expression characterizes the neoplastic transformation of the human gastric mucosa. In: American Journal of Pathology. 2001 ; Vol. 159, No. 3. pp. 803-808.
@article{321e46d7a0754f778e857d7c7af3126f,
title = "Phospholipase C δ2 expression characterizes the neoplastic transformation of the human gastric mucosa",
abstract = "The expression, cellular distribution, and activity of PIP2-specific phospholipase C (PLC) in healthy human gastric-mucosa cells have been recently studied in our laboratories and a direct evidence for an almost exclusive expression of PLC β isoforms, with the exception of PLC β4, has been provided. These results addressed our attention to possible modification of PLC expression and activity during neoplastic transformation of the human gastric mucosa. In the present article we present results indicating that PLC δ2 is markedly expressed in type II intestinal metaplasia and in the adenocarcinoma whereas traces of other PLC isoforms were sometime detected. Interestingly, we found that type I intestinal metaplasia was in the majority of the cases PLC δ2-negative, but when expressed, this type of metaplasia generally considered as benignant, always evolved toward neoplastic transformation. These results therefore readdress the question of surveillance of the patients with type I intestinal metaplasia and suggest that PLC δ2 expression might be a possible marker of gastric malignant transformation.",
author = "Marco Marchisio and {Di Baldassarre}, Angela and Domenico Angelucci and Elisabetta Caramelli and Amelia Cataldi and Sergio Castorina and Adriano Antonucci and {Di Giovannantonio}, Luigina and Cosima Schiavone and {Di Biagio}, Rosa and Mirella Falconi and Giorgio Zauli and Sebastiano Miscia",
year = "2001",
language = "English",
volume = "159",
pages = "803--808",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Phospholipase C δ2 expression characterizes the neoplastic transformation of the human gastric mucosa

AU - Marchisio, Marco

AU - Di Baldassarre, Angela

AU - Angelucci, Domenico

AU - Caramelli, Elisabetta

AU - Cataldi, Amelia

AU - Castorina, Sergio

AU - Antonucci, Adriano

AU - Di Giovannantonio, Luigina

AU - Schiavone, Cosima

AU - Di Biagio, Rosa

AU - Falconi, Mirella

AU - Zauli, Giorgio

AU - Miscia, Sebastiano

PY - 2001

Y1 - 2001

N2 - The expression, cellular distribution, and activity of PIP2-specific phospholipase C (PLC) in healthy human gastric-mucosa cells have been recently studied in our laboratories and a direct evidence for an almost exclusive expression of PLC β isoforms, with the exception of PLC β4, has been provided. These results addressed our attention to possible modification of PLC expression and activity during neoplastic transformation of the human gastric mucosa. In the present article we present results indicating that PLC δ2 is markedly expressed in type II intestinal metaplasia and in the adenocarcinoma whereas traces of other PLC isoforms were sometime detected. Interestingly, we found that type I intestinal metaplasia was in the majority of the cases PLC δ2-negative, but when expressed, this type of metaplasia generally considered as benignant, always evolved toward neoplastic transformation. These results therefore readdress the question of surveillance of the patients with type I intestinal metaplasia and suggest that PLC δ2 expression might be a possible marker of gastric malignant transformation.

AB - The expression, cellular distribution, and activity of PIP2-specific phospholipase C (PLC) in healthy human gastric-mucosa cells have been recently studied in our laboratories and a direct evidence for an almost exclusive expression of PLC β isoforms, with the exception of PLC β4, has been provided. These results addressed our attention to possible modification of PLC expression and activity during neoplastic transformation of the human gastric mucosa. In the present article we present results indicating that PLC δ2 is markedly expressed in type II intestinal metaplasia and in the adenocarcinoma whereas traces of other PLC isoforms were sometime detected. Interestingly, we found that type I intestinal metaplasia was in the majority of the cases PLC δ2-negative, but when expressed, this type of metaplasia generally considered as benignant, always evolved toward neoplastic transformation. These results therefore readdress the question of surveillance of the patients with type I intestinal metaplasia and suggest that PLC δ2 expression might be a possible marker of gastric malignant transformation.

UR - http://www.scopus.com/inward/record.url?scp=0034741778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034741778&partnerID=8YFLogxK

M3 - Article

C2 - 11549571

AN - SCOPUS:0034741778

VL - 159

SP - 803

EP - 808

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 3

ER -