Phospholipids bound to the non histone chromosomal proteins of human peripheral lymphocytes

L. Cocco, S. Capitani, A. Facchini

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

DNA and histone fractions did not show the presence of lipids detectable by thin layer chromatography (TLC), whereas the non histone chromosomal protein (NHCP) contained approximately 2% lipids in dry weight. As revealed by TLC, all NHCP bound lipids were phospholipids, i.e. sphingomyelin, phosphatidylethanolamine and phosphatidylcholine. The phospholipid pattern and the ratio of sphingomyelin, phosphatidylethanolamine and phosphatidylcholine (about 5:4:1) bound to NHCP of peripheral blood lymphocytes were different from the phospholipid composition of calf thymus lymphocyte chromatin from the nuclear membrane and other membrane fractions.

Original languageEnglish
Title of host publicationIRCS MED.SCI.BIOCHEM.
Pages451
Number of pages1
Volume3
Edition9
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Medicine(all)

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