Phosphorus magnetic resonance spectroscopy in multiple system atrophy and Parkinson's disease

Bruno Barbiroli, Paolo Martinelli, Alberto Patuelli, Raffaele Lodi, Stefano Iotti, Pietro Cortelli, Pasquale Montagna

Research output: Contribution to journalArticle

Abstract

We performed in vivo phosphorus magnetic resonance spectroscopy on the occipital lobes of 15 patients with multiple system atrophy (MSA; eight with olivopontocerebellar atrophy [OPCA] and seven with the striatonigral degeneration variant [SND]), 13 patients with idiopathic Parkinson's disease (PD), and 16 age-matched healthy subjects. The MSA group showed significantly reduced phosphocreatine (PCr), increased inorganic phosphate (Pi), and unchanged cytosolic free [Mg2+], and pH. We did not find any significant difference between the OPCA and SND variants. However, patients with PD showed significantly increased content of Pi, decreased cytosolic free [Mg2+], and unchanged [PCr] and pH. Comparing the MSA and PD groups, [PCr] was significantly lower in MSA than in PD, whereas cytosolic free [Mg2+] was significantly lower in PD. Despite a certain degree of overlap of [PCr] and [Mg2+] values between the two groups, by considering both variables at the same time it was possible to classify correctly 93% of cases by discriminant analysis. We conclude that phosphorus magnetic resonance spectroscopy discloses abnormal phosphate metabolite and ion contents in both MSA and PD, respectively, and may provide noninvasive diagnostic help to differentiate MSA from PD.

Original languageEnglish
Pages (from-to)430-435
Number of pages6
JournalMovement Disorders
Volume14
Issue number3
DOIs
Publication statusPublished - 1999

Fingerprint

Multiple System Atrophy
Phosphorus
Parkinson Disease
Magnetic Resonance Spectroscopy
Phosphocreatine
Olivopontocerebellar Atrophies
Striatonigral Degeneration
Phosphates
Occipital Lobe
Discriminant Analysis
Healthy Volunteers
Ions

Keywords

  • Brain
  • Magnesium
  • Multiple system atrophy
  • Parkinson's disease
  • Phosphocreatine
  • Phosphorus magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Phosphorus magnetic resonance spectroscopy in multiple system atrophy and Parkinson's disease. / Barbiroli, Bruno; Martinelli, Paolo; Patuelli, Alberto; Lodi, Raffaele; Iotti, Stefano; Cortelli, Pietro; Montagna, Pasquale.

In: Movement Disorders, Vol. 14, No. 3, 1999, p. 430-435.

Research output: Contribution to journalArticle

Barbiroli, Bruno ; Martinelli, Paolo ; Patuelli, Alberto ; Lodi, Raffaele ; Iotti, Stefano ; Cortelli, Pietro ; Montagna, Pasquale. / Phosphorus magnetic resonance spectroscopy in multiple system atrophy and Parkinson's disease. In: Movement Disorders. 1999 ; Vol. 14, No. 3. pp. 430-435.
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