Photic reflex myoclonus: A neurophysiological study in progressive myoclonus epilepsies

Guido Rubboli, Stefano Meletti, Elena Gardella, Anna Zaniboni, Giuseppe D'Orsi, Charlotte Dravet, Carlo Alberto Tassinari

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate the neurophysiological features of photic reflex myoclonus (PRM) in patients with progressive myoclonus epilepsies (PMEs) of different types (Unverricht-Lundborg disease, Lafora's disease, cryptogenic). Methods: All patients underwent computerized video-polygraphic recordings, collecting electromyographic (EMG) activity from several cranial and limb muscles. PRM was elicited by intermittent photic stimulation (IPS). Results: IPS could evoke PRM with a 1:1 relation at frequencies up to 12 Hz. Back- average of the EEG, triggered from the onset of PRM at the upper limbs, showed a contralateral positive-negative transient in central region, preceded by ~10 ms by a similar, ipsilateral occipital wave. When IPS induced bilateral jerking, a time lag of ~10 ms between the homologous muscles of the two sides was observed, paralleled by a similar delay between the associated contralateral EEG transients in the two central regions, suggesting spread of cortical myoclonic activity from one hemisphere to the other via transcallosal fibers. PRM propagated in different cranial and limb muscles according to a rostrocaudal pattern, with latencies compatible with a transmission along fast-conducting corticospinal motor pathways. Conclusions: In our PME patients, PRM presented uniform neurophysiological features, indicating the participation of both occipital and motor cortices, with bilateral spread presumably mediated by transcallosal connections and propagation down the spinal cord via fast-conducting corticospinal pathways.

Original languageEnglish
Pages (from-to)50-58
Number of pages9
JournalEpilepsia
Volume40
Issue number9 SUPPL. 4
Publication statusPublished - 1999

Fingerprint

Progressive Myoclonic Epilepsy
Myoclonus
Reflex
Photic Stimulation
Muscles
Electroencephalography
Unverricht-Lundborg Syndrome
Lafora Disease
Extremities
Efferent Pathways
Occipital Lobe
Video Recording
Motor Cortex
Upper Extremity
Spinal Cord

Keywords

  • Myoclonus
  • Photic reflex myoclonus
  • Photosensitivity
  • Polygraphy
  • Progressive myoclonus epilepsies

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Rubboli, G., Meletti, S., Gardella, E., Zaniboni, A., D'Orsi, G., Dravet, C., & Tassinari, C. A. (1999). Photic reflex myoclonus: A neurophysiological study in progressive myoclonus epilepsies. Epilepsia, 40(9 SUPPL. 4), 50-58.

Photic reflex myoclonus : A neurophysiological study in progressive myoclonus epilepsies. / Rubboli, Guido; Meletti, Stefano; Gardella, Elena; Zaniboni, Anna; D'Orsi, Giuseppe; Dravet, Charlotte; Tassinari, Carlo Alberto.

In: Epilepsia, Vol. 40, No. 9 SUPPL. 4, 1999, p. 50-58.

Research output: Contribution to journalArticle

Rubboli, G, Meletti, S, Gardella, E, Zaniboni, A, D'Orsi, G, Dravet, C & Tassinari, CA 1999, 'Photic reflex myoclonus: A neurophysiological study in progressive myoclonus epilepsies', Epilepsia, vol. 40, no. 9 SUPPL. 4, pp. 50-58.
Rubboli G, Meletti S, Gardella E, Zaniboni A, D'Orsi G, Dravet C et al. Photic reflex myoclonus: A neurophysiological study in progressive myoclonus epilepsies. Epilepsia. 1999;40(9 SUPPL. 4):50-58.
Rubboli, Guido ; Meletti, Stefano ; Gardella, Elena ; Zaniboni, Anna ; D'Orsi, Giuseppe ; Dravet, Charlotte ; Tassinari, Carlo Alberto. / Photic reflex myoclonus : A neurophysiological study in progressive myoclonus epilepsies. In: Epilepsia. 1999 ; Vol. 40, No. 9 SUPPL. 4. pp. 50-58.
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