Photochemistry and DNA-affinity of some pyrimidine-substituted styryl-azinium iodides

Alessandra Mazzoli, Benedetta Carlotti, Carmela Bonaccorso, Cosimo G. Fortuna, Ugo Mazzucato, Giorgia Miolo, Anna Spalletti

Research output: Contribution to journalArticle

Abstract

The relaxation properties of the excited states of three iodides of trans-1,2-diarylethene analogues (where one aryl group is a methylpyridinium, methylquinolinium or dimethylimidazolium group and the other one is a phenyl ring para-substituted by a pyrimidine ring) have been investigated in buffered (pH = 7) aqueous solution. As found in previous works for several analogues, these quaternized salts undergo efficient trans → cis photoisomerization while the yield of the radiative deactivation is very small at room temperature. The solvent effect on the spectral behaviour indicates the occurrence of intramolecular charge transfer which can induce interesting non-linear optical properties. The results of a study of the interactions of these salts with DNA, which might affect the cell metabolism, showed a relatively modest binding affinity for the pyridinium and imidazolium salts and a more substantial affinity for the quinolinium analogue. The formation of ligand-DNA complexes affects only slightly the radiative relaxation yield while leading to a relevant reduction of the isomerization yield. Measurements of the linear dichroism behaviour of the three compounds and comparison with three analogues bearing furan or thienyl groups, which have been found to display different affinity with DNA in previous works, gave interesting information on the nature of the ligand-DNA binding of these compounds.

Original languageEnglish
Pages (from-to)1830-1836
Number of pages7
JournalPhotochemical and Photobiological Sciences
Volume10
Issue number11
DOIs
Publication statusPublished - Nov 2011

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'Photochemistry and DNA-affinity of some pyrimidine-substituted styryl-azinium iodides'. Together they form a unique fingerprint.

  • Cite this