Photo(chemo)therapy for vitiligo

Alessia Pacifico, Giovanni Leone

Research output: Contribution to journalArticlepeer-review


Vitiligo is a common skin disease characterized by loss of normal melanin pigments in the skin and its pathogenesis is still unclear. Treatment modalities include psoralen plus ultraviolet A, narrow-band ultraviolet B (NB UVB) phototherapy, topical and systemic steroids, topical calcineurin inhibitors, topical vitamin D analogues in monotherapy or in association with phototherapy, and surgical treatment. NB UVB (310-315nm) radiation is now considered as the 'gold standard' for the treatment of diffuse vitiligo, and treatment with two recently introduced UVB sources that emit 308nm wavelengths, the 308nm xenon chloride (XeCl) excimer laser and the 308nm XeCl excimer light, has also been reported to be effective and might be the treatment of choice for localized disease: this treatment modality has been defined as 'targeted phototherapy.'

Original languageEnglish
Pages (from-to)261-277
Number of pages17
JournalPhotodermatology Photoimmunology and Photomedicine
Issue number5
Publication statusPublished - Oct 2011


  • Excimer laser
  • Excimer light
  • Narrow-band UVB
  • PUVA
  • Targeted phototherapy
  • Vitiligo

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy
  • Immunology
  • Radiology Nuclear Medicine and imaging


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