TY - JOUR
T1 - Photodynamic therapy in subfoveal and juxtafoveal myopic choroidal neovascularization
T2 - A 10-year retrospective analysis
AU - Varano, Monica
AU - Iacono, Pierluigi
AU - Giorno, Paola
AU - Chiaravalloti, Adele
AU - Parravano, Mariacristina
PY - 2014
Y1 - 2014
N2 - The aim of this study was to evaluate and compare the effects of photodynamic therapy (PDT) in eyes with subfoveal and juxtafoveal choroidal neovascularization (CNV) secondary to pathological myopia. The study was a single-center, 10-year analysis on 19 eyes. Patients underwent best-corrected visual acuity (BCVA) measurement, slit-lamp examination, ophthalmoscopy and fluorescein angiography. Eyes with subfoveal CNV (7 eyes, 37%) progressively worsened during the 10-year follow-up from 0.68 ± 0.26 to 0.80 ± 0.47 logMAR, while in the eyes with juxtafoveal CNV (12 eyes, 63%) BCVA improved from 0.59 ± 0.42 to 0.33 ± 0.27 logMAR. Prevalence and extension of chorioretinal atrophy (CRA) were greater in eyes with subfoveal compared with juxtafoveal CNV (84 vs. 66%, respectively) and enlargement (10.05 ± 6.7 vs. 3.53 ± 4.7 mm2, respectively). Our results confirm the limited long-term effectiveness of PDT in myopic subfoveal CNV. Satisfactory results can be achieved in juxtafoveal CNV with a better visual outcome and a minor CRA extension.
AB - The aim of this study was to evaluate and compare the effects of photodynamic therapy (PDT) in eyes with subfoveal and juxtafoveal choroidal neovascularization (CNV) secondary to pathological myopia. The study was a single-center, 10-year analysis on 19 eyes. Patients underwent best-corrected visual acuity (BCVA) measurement, slit-lamp examination, ophthalmoscopy and fluorescein angiography. Eyes with subfoveal CNV (7 eyes, 37%) progressively worsened during the 10-year follow-up from 0.68 ± 0.26 to 0.80 ± 0.47 logMAR, while in the eyes with juxtafoveal CNV (12 eyes, 63%) BCVA improved from 0.59 ± 0.42 to 0.33 ± 0.27 logMAR. Prevalence and extension of chorioretinal atrophy (CRA) were greater in eyes with subfoveal compared with juxtafoveal CNV (84 vs. 66%, respectively) and enlargement (10.05 ± 6.7 vs. 3.53 ± 4.7 mm2, respectively). Our results confirm the limited long-term effectiveness of PDT in myopic subfoveal CNV. Satisfactory results can be achieved in juxtafoveal CNV with a better visual outcome and a minor CRA extension.
KW - Choroidal neovascularization
KW - Myopia
KW - Photodynamic therapy
UR - http://www.scopus.com/inward/record.url?scp=84900549817&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900549817&partnerID=8YFLogxK
U2 - 10.1159/000357504
DO - 10.1159/000357504
M3 - Article
C2 - 24481122
AN - SCOPUS:84900549817
VL - 231
SP - 204
EP - 210
JO - Ophthalmologica
JF - Ophthalmologica
SN - 0030-3755
IS - 4
ER -