Photodynamic therapy outcomes in a case of macular choroidal neovascularization secondary to Candida endophthalmitis

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Abstract

PURPOSE. To evaluate the effects on visual function and choroidal neovascularization (CNV) progression in a case of subretinal CNV due to Candida endophthalmitis treated with a combination of photodynamic therapy (PDT) and drugs. METHODS. A 28-year-old one-eyed woman with CNV in the right eye came to our observation. The CNV developed as a consequence of Candida endophthalmitis. The CNV was treated with six PDT treatments with verteporfin in association with systemic steroid therapy with prednisone (100 mg/day to reduce) and fluconazole (800 mg/day to reduce). Visual acuity (VA) was assessed in pre-PDT conditions and after six PDT treatments (24 months of follow-up). RESULTS. Pre-PDT VA was 20/125; after 24 months of follow-up, six PDT re-treatments, and pharmacologic therapy, VA was stabilized at 20/100. CONCLUSIONS. In our case, associated PDT and drug therapies were safe and useful to maintain VA and to arrest CNV progression in the foveal region after 2 years of follow-up.

Original languageEnglish
Pages (from-to)124-127
Number of pages4
JournalEuropean Journal of Ophthalmology
Volume17
Issue number1
Publication statusPublished - Jan 2007

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Choroidal Neovascularization
Endophthalmitis
Photochemotherapy
Candida
Visual Acuity
Therapeutics
Fluconazole
Prednisone
Combination Drug Therapy
Steroids
Observation
Drug Therapy

Keywords

  • Candida albicans
  • Choroidal neovascularization
  • Photodynamic therapy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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title = "Photodynamic therapy outcomes in a case of macular choroidal neovascularization secondary to Candida endophthalmitis",
abstract = "PURPOSE. To evaluate the effects on visual function and choroidal neovascularization (CNV) progression in a case of subretinal CNV due to Candida endophthalmitis treated with a combination of photodynamic therapy (PDT) and drugs. METHODS. A 28-year-old one-eyed woman with CNV in the right eye came to our observation. The CNV developed as a consequence of Candida endophthalmitis. The CNV was treated with six PDT treatments with verteporfin in association with systemic steroid therapy with prednisone (100 mg/day to reduce) and fluconazole (800 mg/day to reduce). Visual acuity (VA) was assessed in pre-PDT conditions and after six PDT treatments (24 months of follow-up). RESULTS. Pre-PDT VA was 20/125; after 24 months of follow-up, six PDT re-treatments, and pharmacologic therapy, VA was stabilized at 20/100. CONCLUSIONS. In our case, associated PDT and drug therapies were safe and useful to maintain VA and to arrest CNV progression in the foveal region after 2 years of follow-up.",
keywords = "Candida albicans, Choroidal neovascularization, Photodynamic therapy",
author = "Massimiliano Tedeschi and M. Varano and {Schiano Lomoriello}, D. and C. Scassa and V. Parisi",
year = "2007",
month = "1",
language = "English",
volume = "17",
pages = "124--127",
journal = "European Journal of Ophthalmology",
issn = "1120-6721",
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TY - JOUR

T1 - Photodynamic therapy outcomes in a case of macular choroidal neovascularization secondary to Candida endophthalmitis

AU - Tedeschi, Massimiliano

AU - Varano, M.

AU - Schiano Lomoriello, D.

AU - Scassa, C.

AU - Parisi, V.

PY - 2007/1

Y1 - 2007/1

N2 - PURPOSE. To evaluate the effects on visual function and choroidal neovascularization (CNV) progression in a case of subretinal CNV due to Candida endophthalmitis treated with a combination of photodynamic therapy (PDT) and drugs. METHODS. A 28-year-old one-eyed woman with CNV in the right eye came to our observation. The CNV developed as a consequence of Candida endophthalmitis. The CNV was treated with six PDT treatments with verteporfin in association with systemic steroid therapy with prednisone (100 mg/day to reduce) and fluconazole (800 mg/day to reduce). Visual acuity (VA) was assessed in pre-PDT conditions and after six PDT treatments (24 months of follow-up). RESULTS. Pre-PDT VA was 20/125; after 24 months of follow-up, six PDT re-treatments, and pharmacologic therapy, VA was stabilized at 20/100. CONCLUSIONS. In our case, associated PDT and drug therapies were safe and useful to maintain VA and to arrest CNV progression in the foveal region after 2 years of follow-up.

AB - PURPOSE. To evaluate the effects on visual function and choroidal neovascularization (CNV) progression in a case of subretinal CNV due to Candida endophthalmitis treated with a combination of photodynamic therapy (PDT) and drugs. METHODS. A 28-year-old one-eyed woman with CNV in the right eye came to our observation. The CNV developed as a consequence of Candida endophthalmitis. The CNV was treated with six PDT treatments with verteporfin in association with systemic steroid therapy with prednisone (100 mg/day to reduce) and fluconazole (800 mg/day to reduce). Visual acuity (VA) was assessed in pre-PDT conditions and after six PDT treatments (24 months of follow-up). RESULTS. Pre-PDT VA was 20/125; after 24 months of follow-up, six PDT re-treatments, and pharmacologic therapy, VA was stabilized at 20/100. CONCLUSIONS. In our case, associated PDT and drug therapies were safe and useful to maintain VA and to arrest CNV progression in the foveal region after 2 years of follow-up.

KW - Candida albicans

KW - Choroidal neovascularization

KW - Photodynamic therapy

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