Photodynamic therapy using a methyl ester of 5-aminolevulinic acid in recurrent Paget's disease of the vulva: A pilot study

F. Raspagliesi, R. Fontanelli, G. Rossi, A. Ditto, E. Solima, F. Hanozet, S. Kusamura

Research output: Contribution to journalArticle

Abstract

Objective.: In the past, treating vulvar Paget's disease through surgery has resulted in a high recurrence rate of the disease. Photodynamic therapy (PDT) using 5-aminolevulinic acid (5 ALA) is an effective treatment for some conditions such as Bowen's disease, subsets of basal cell carcinomas and vulvar carcinoma. Methyl 5-aminolevulinate (MAL) is an ester of 5 ALA that seems to be more effective and produces fewer side effects than 5 ALA. This paper outlines a pilot study designed to test the feasibility of using MAL-PDT in the treatment of recurrent vulvar Paget's disease. Methods.: 5 MAL-PDT was applied for 3 h and than irradiated with red-light (620 nm) using a total light dose of 37 J/cm2 for a period of 10 min. Patients taking part in the study were treated once every 3 weeks, for a total of three treatments. Vulvar biopsies were obtained before and 1 month after the PDT-treatment. Results.: Seven patients were enrolled in the study. Four cases had a complete clinical response, and this was pathologically confirmed in two of the cases. The cosmetic outcome was acceptable and the treatment was well tolerated. All the patients developed local edema and mild local pain, controlled with non-steroidal antiinflammatory drugs (NSAIDS). One patient experienced severe pain and a mild local phototoxicity reaction. Conclusions.: MAL-PDT is a feasible treatment and seems to offer a reliable strategy in the control of vulvar Paget's disease and of its symptoms.

Original languageEnglish
Pages (from-to)581-586
Number of pages6
JournalGynecologic Oncology
Volume103
Issue number2
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Vulva
Photochemotherapy
Vulvar Diseases
Aminolevulinic Acid
Therapeutics
Bowen's Disease
Phototoxic Dermatitis
Light
Pain
Basal Cell Carcinoma
Cosmetics
delta-aminolevulinic acid methyl ester
Edema
Esters
Anti-Inflammatory Agents
Carcinoma
Biopsy
Recurrence
methyl 5-aminolevulinate
Pharmaceutical Preparations

Keywords

  • Photodynamic therapy
  • Vulvar Paget's disease

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Photodynamic therapy using a methyl ester of 5-aminolevulinic acid in recurrent Paget's disease of the vulva : A pilot study. / Raspagliesi, F.; Fontanelli, R.; Rossi, G.; Ditto, A.; Solima, E.; Hanozet, F.; Kusamura, S.

In: Gynecologic Oncology, Vol. 103, No. 2, 11.2006, p. 581-586.

Research output: Contribution to journalArticle

Raspagliesi, F. ; Fontanelli, R. ; Rossi, G. ; Ditto, A. ; Solima, E. ; Hanozet, F. ; Kusamura, S. / Photodynamic therapy using a methyl ester of 5-aminolevulinic acid in recurrent Paget's disease of the vulva : A pilot study. In: Gynecologic Oncology. 2006 ; Vol. 103, No. 2. pp. 581-586.
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