Photodynamic therapy vs. imiquimod 5% cream as skin cancer preventive strategies in patients with field changes: A randomized intraindividual comparison study

E. Sotiriou, Z. Apalla, F. Vrani, A. Lallas, E. Chovarda, D. Ioannides

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Actinic damage is responsible for the development of multiple, recurrent non-melanoma skin cancers (NMSCs), including actinic keratoses (AKs). Photodynamic therapy (PDT) and imiquimod cream (IMIQ) 5% are recommended as field-directed treatment options. Objectives: To compare efficacy and safety of methyl aminolevulinate (MAL)-PDT vs. IMIQ 5% in the prevention of new NMSCs development patients with field changes. Methods: Patients with field cancerization of the face or scalp were randomized to receive MAL-PDT on one side, and IMIQ 5% on the mirror field. The primary endpoint was the number of new lesions on the treated fields during a 12-month follow-up period. Secondary assessments included adverse events and patient preference. Results: Forty-four patients completed the study. MAL-PDT and IMIQ did not differ concerning the primary endpoint, as there was no statistically significant difference in terms of development of new NMSCs at any point of follow-up. Both treatment regimens were safe and well tolerated. Patients' preference based on the procedure, response rates and future choice favoured MAL-PDT. Conclusions: MAL-PDT and IMIQ 5% are safe and well-tolerated treatments that equally prevent development of new AKs in patients suffering from field changes. MAL-PDT treatment appears to be superior in terms of patients' preference.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalJournal of the European Academy of Dermatology and Venereology
Volume29
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases
  • Medicine(all)

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