Photodynamic Therapy With Verteporfin of Choroidal Malignancy From Breast Cancer

Vincenzo Isola; Alfredo Pece; Luisa Pierro

doi:10.1016/j.ajo.2006.06.008

Photodynamic Therapy With Verteporfin of Choroidal Malignancy From Breast Cancer

Vincenzo Isola, Alfredo Pece, Luisa Pierro

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

Purpose: To evaluate the effectiveness of photodynamic therapy (PDT) with verteporfin for treating a submacular choroidal metastasis from breast cancer. Design: Interventional case report. Methods: Multispot PDT irradiation of tumor surface was performed in a 45-year-old woman who had a choroidal metastasis from breast cancer in the right eye. The response of uveal metastasis to photodynamic action was investigated with the use of fluorescein angiography and optical coherence tomography (OCT). Results: Within four months after photosensitization, the exudative detachment of the macula was resolved, with improvement in the visual acuity following decrease in the tumor vascular permeability and absorption of subretinal fluid. Conclusions: PDT can effectively destroy a malignant tissue and induce an antitumor activity. PDT as an adjunct to chemotherapy is a possible treatment and might be appropriate for patients who require ocular treatment only.

Original language	English
Pages (from-to)	885-887
Number of pages	3
Journal	American Journal of Ophthalmology
Volume	142
Issue number	5
DOIs	https://doi.org/10.1016/j.ajo.2006.06.008
Publication status	Published - Nov 2006

ASJC Scopus subject areas

Ophthalmology

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Isola, V., Pece, A., & Pierro, L. (2006). Photodynamic Therapy With Verteporfin of Choroidal Malignancy From Breast Cancer. American Journal of Ophthalmology, 142(5), 885-887. https://doi.org/10.1016/j.ajo.2006.06.008

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abstract = "Purpose: To evaluate the effectiveness of photodynamic therapy (PDT) with verteporfin for treating a submacular choroidal metastasis from breast cancer. Design: Interventional case report. Methods: Multispot PDT irradiation of tumor surface was performed in a 45-year-old woman who had a choroidal metastasis from breast cancer in the right eye. The response of uveal metastasis to photodynamic action was investigated with the use of fluorescein angiography and optical coherence tomography (OCT). Results: Within four months after photosensitization, the exudative detachment of the macula was resolved, with improvement in the visual acuity following decrease in the tumor vascular permeability and absorption of subretinal fluid. Conclusions: PDT can effectively destroy a malignant tissue and induce an antitumor activity. PDT as an adjunct to chemotherapy is a possible treatment and might be appropriate for patients who require ocular treatment only.",

author = "Vincenzo Isola and Alfredo Pece and Luisa Pierro",

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AU - Pierro, Luisa

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N2 - Purpose: To evaluate the effectiveness of photodynamic therapy (PDT) with verteporfin for treating a submacular choroidal metastasis from breast cancer. Design: Interventional case report. Methods: Multispot PDT irradiation of tumor surface was performed in a 45-year-old woman who had a choroidal metastasis from breast cancer in the right eye. The response of uveal metastasis to photodynamic action was investigated with the use of fluorescein angiography and optical coherence tomography (OCT). Results: Within four months after photosensitization, the exudative detachment of the macula was resolved, with improvement in the visual acuity following decrease in the tumor vascular permeability and absorption of subretinal fluid. Conclusions: PDT can effectively destroy a malignant tissue and induce an antitumor activity. PDT as an adjunct to chemotherapy is a possible treatment and might be appropriate for patients who require ocular treatment only.

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