Photofrin II as an efficient radiosensitizing agent in an experimental tumor

M. Schaffer, P. M. Schaffer, L. Corti, G. Sotti, A. Hofstetter, G. Jori, E. Dühmke

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objective: The use of ionizing irradiation as radiation therapy (RT) for tumor treatment represents a well-established method. The use of photodynamic therapy (PDT), especially with Photofrin II, for tumor treatment is also known. Chemical modifiers enhancing the action of radiation therapy are well known and widely used in medicine. None of these compounds, however, is a selective radiosensitizer. Materials and Methods: Several series of animal experiments were performed. The highly differentiated human bladder cancer cell line RT4 was implanted subcutaneously in nude mice. The mice were injected 10 mg/kg Photofrin II and irradiated with 5 Gy. Results: Photofrin II has proved to be a chemical modifier of ionizing irradiation, enhancing the tumor doubling time (tumor growth) from 6.2 to 10.9 days in the control group with the use of irradiation and injection of porphyrin. Conclusion: Photofrin II shows a high activity as radiosensitizer and, in the future, can be used as a selective radiosensitizer for tumor treatment with ionizing radiation.

Original languageEnglish
Pages (from-to)482-485
Number of pages4
JournalOnkologie
Volume24
Issue number5
DOIs
Publication statusPublished - 2001

Keywords

  • Ionizing irradiation
  • Photodynamic therapy
  • Photofrin II
  • Radiation therapy
  • Radiosensitizer

ASJC Scopus subject areas

  • Oncology

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