Photopenic Defects in Gliomas With Amino-Acid PET and Relative Prognostic Value: A Multicentric 11C-Methionine and 18F-FDOPA PET Experience

Timothée Zaragori, Angelo Castello, Eric Guedj, Antoine Girard, Norbert Galldiks, Nathalie L Albert, Egesta Lopci, Antoine Verger

Research output: Contribution to journalArticlepeer-review

Abstract

The aim is to explore the concept of photopenic defects in newly diagnosed glioma patients with the 2 widely used C-MET and F-FDOPA PET amino acid tracers. Thirty-two C-MET and 26 F-FDOPA PET scans with amino acid PET-negative gliomas were selected in this European multicentric study. Of these gliomas, 16 C-MET and 10 F-FDOPA PET scans with photopenic defects were identified, exhibiting lower mean tumor-to-background ratio as compared with isometabolic gliomas (P < 0.001). Gliomas with photopenic defects had no different progression-free survival than isometabolic gliomas in the whole population (P = 0.40), but shorter progression-free survival in the subgroup of World Health Organization grade II IDH-mutant astrocytomas (35 vs 68 months; P = 0.047).

Original languageEnglish
Pages (from-to)e36-e37
JournalClinical Nuclear Medicine
Volume46
Issue number1
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Adult
  • Aged
  • Brain Neoplasms/diagnostic imaging
  • Dihydroxyphenylalanine/analogs & derivatives
  • Female
  • Glioma/diagnostic imaging
  • Humans
  • Male
  • Methionine
  • Middle Aged
  • Positron-Emission Tomography
  • Progression-Free Survival

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