BACKGROUND: Photophobia has never been investigated in MS.
METHODS: In this pilot study we used photosensitivity questionnaire assessment (PAQ) to evaluate tolerability to light in 73 MS patients and 62 healthy controls.
RESULTS: We identified a lower PAQ score and a higher number of photophobic subjects in MS than in controls. Moreover, clinical disability or previous optic neuritis did not predict the photosensitivity profile.
CONCLUSION: Further studies to investigate the pathophysiological mechanisms underlying photophobia in MS are needed.