Phylogenetic analysis of rubella virus isolated during a period of epidemic transmission in Italy, 1991-1997

Du Ping Zheng, Hong Zhu, Maria G. Revello, Giuseppe Gerna, Teryl K. Frey

Research output: Contribution to journalArticle

Abstract

To study the molecular epidemiology of rubella virus during endemic transmission, phylogenetic analysis of the nucleotide sequence of the E1 gene was done with 31 isolates collected in northern Italy durin 1991-1997, a period spanning 3 epidemics. The viruses segregated into distinct genotypic strains. Cocirculation of genotypic strains was detected; however, each epidemic was associated with specific strains, and strain displacement occurred concomitantly with each epidemic. Although most of the viruses from Italy belonged to rubella genotype I and many were related to viruses isolated concurrently in other European countries, 3 viruses belonged to rubella genotype II, which previously had been isolated only in Asia. Thus, intercontinental importation of viruses also occurred.

Original languageEnglish
Pages (from-to)1587-1597
Number of pages11
JournalJournal of Infectious Diseases
Volume187
Issue number10
DOIs
Publication statusPublished - May 15 2003

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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