Phylogenetic analysis of the surface proteins of influenza a (H5N1) viruses isolated in asian and african populations

Muhammed Babakir-Mina, Massimo Ciccozzi, Marco Ciotti, Fabio Marcuccilli, Emanuela Balestra, Salvatore Dimonte, Carlo Federico Perno, Stefano Aquaro

Research output: Contribution to journalArticlepeer-review

Abstract

Highly pathogenic H5N1 virus can infect a variety of animals and continually poses a threat to animal and human health. Here, phylogenetic analysis of the hemagglutinin and neuraminidase genes indicated that the hemagglutinin gene of all human isolates, although very similar to each other, fell within different clades corresponding to antigenically distinguishable variants. Likewise, the Nl neuraminidase gene forms a clade that is evolutionarily distinct from previously characterized Nl neuraminidases. So, although all H5N1 viruses were derived from ancestors circulating in south-east Asia more than ten years ago, since 2003 they have evolved into geographically distinct groups within each country.

Original languageEnglish
Pages (from-to)397-403
Number of pages7
JournalNew Microbiologica
Volume32
Issue number4
Publication statusPublished - Oct 2009

Keywords

  • Flu pandemic
  • Genetic evolution
  • H5n1 surface antigens
  • H5n1 virus
  • Phylogenetic analysis

ASJC Scopus subject areas

  • Microbiology (medical)

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