Phylogeographical footprint of colonial history in the global dispersal of human immunodeficiency virus type 2 group A

Nuno R. Faria, Ioannis Hodges-Mameletzis, Joana C. Silva, Berta Rodés, Smit Erasmus, Stefania Paolucci, Jean Ruelle, Danuta Pieniazek, Nuno Taveira, Ana Treviño, Maria F. Gonçalves, Sabelle Jallow, Li Xu, Ricardo J. Camacho, Vincent Soriano, Patrick Goubau, João D. de Sousa, Anne Mieke Vandamme, Marc A. Suchard, Philippe Lemey

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Abstract

Human immunodeficiency virus type 2 (HIV-2) emerged in West Africa and has spread further to countries that share socio-historical ties with this region. However, viral origins and dispersal patterns at a global scale remain poorly understood. Here, we adopt a Bayesian phylogeographic approach to investigate the spatial dynamics of HIV-2 group A (HIV-2A) using a collection of 320 partial pol and 248 partial env sequences sampled throughout 19 countries worldwide. We extend phylogenetic diffusion models that simultaneously draw information from multiple loci to estimate location states throughout distinct phylogenies and explicitly attempt to incorporate human migratory fluxes. Our study highlights that Guinea-Bissau, together with Côte d'Ivoire and Senegal, have acted as the main viral sources in the early stages of the epidemic. We show that convenience sampling can obfuscate the estimation of the spatial root of HIV-2A. We explicitly attempt to circumvent this by incorporating rate priors that reflect the ratio of human flow from and toWest Africa.We recover four main routes of HIV-2A dispersal that are laid out along colonial ties: Guinea-Bissau and Cape Verde to Portugal, Côte d'Ivoire and Senegal to France. Within Europe, we find strong support for epidemiological linkage from Portugal to Luxembourg and to the UK. We demonstrate that probabilistic models can uncover global patterns of HIV-2A dispersal providing sampling bias is taken into account and we provide a scenario for the international spread of this virus.

Original languageEnglish
Pages (from-to)889-899
Number of pages11
JournalJournal of General Virology
Volume93
Issue number4
DOIs
Publication statusPublished - Apr 2012

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ASJC Scopus subject areas

  • Virology

Cite this

Faria, N. R., Hodges-Mameletzis, I., Silva, J. C., Rodés, B., Erasmus, S., Paolucci, S., Ruelle, J., Pieniazek, D., Taveira, N., Treviño, A., Gonçalves, M. F., Jallow, S., Xu, L., Camacho, R. J., Soriano, V., Goubau, P., de Sousa, J. D., Vandamme, A. M., Suchard, M. A., & Lemey, P. (2012). Phylogeographical footprint of colonial history in the global dispersal of human immunodeficiency virus type 2 group A. Journal of General Virology, 93(4), 889-899. https://doi.org/10.1099/vir.0.038638-0