Physical activity and exercise as countermeasures to physical frailty and sarcopenia

Emanuele Marzetti, Riccardo Calvani, Matteo Tosato, Matteo Cesari, Mauro Di Bari, Antonio Cherubini, Marianna Broccatelli, Giulia Savera, Mariaelena D’Elia, Marco Pahor, Roberto Bernabei, Francesco Landi, on behalf of the SPRINTT Consortium

Research output: Contribution to journalArticlepeer-review


The identification of cost-effective interventions that improve the health status and prevent disability in old age is one of the most important public health challenges. Regular physical activity is the only intervention that has consistently been shown to improve functional health and energy balance and to reduce the risk of cardiovascular disease, stroke, diabetes, several cancers, depression and falls. In advanced age, physical activity is also effective at mitigating sarcopenia, restoring robustness, and preventing/delaying the development of disability. On the other hand, physical inactivity is recognized as one of the leading causes of several chronic degenerative diseases and is also a major contributing factor to sarcopenia and functional disability. This compelling evidence has prompted the World Health Organization to recommend engaging in regular physical activity throughout one’s life course. The present review summarizes the available evidence in support of physical activity as a remedy against physical frailty and sarcopenia. The relevant pathways through which the benefits of physical activity are conveyed are also discussed.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalAging clinical and experimental research
Issue number1
Publication statusPublished - Feb 1 2017


  • Endurance training
  • Exercise
  • Physical performance
  • Resistance training
  • Skeletal muscle

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology


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