TY - JOUR
T1 - Physical activity and exercise as countermeasures to physical frailty and sarcopenia
AU - Marzetti, Emanuele
AU - Calvani, Riccardo
AU - Tosato, Matteo
AU - Cesari, Matteo
AU - Bari, Mauro Di
AU - Cherubini, Antonio
AU - Broccatelli, Marianna
AU - Savera, Giulia
AU - D’Elia, Mariaelena
AU - Pahor, Marco
AU - Bernabei, Roberto
AU - Landi, Francesco
AU - on behalf of the SPRINTT Consortium
PY - 2017/2/1
Y1 - 2017/2/1
N2 - The identification of cost-effective interventions that improve the health status and prevent disability in old age is one of the most important public health challenges. Regular physical activity is the only intervention that has consistently been shown to improve functional health and energy balance and to reduce the risk of cardiovascular disease, stroke, diabetes, several cancers, depression and falls. In advanced age, physical activity is also effective at mitigating sarcopenia, restoring robustness, and preventing/delaying the development of disability. On the other hand, physical inactivity is recognized as one of the leading causes of several chronic degenerative diseases and is also a major contributing factor to sarcopenia and functional disability. This compelling evidence has prompted the World Health Organization to recommend engaging in regular physical activity throughout one’s life course. The present review summarizes the available evidence in support of physical activity as a remedy against physical frailty and sarcopenia. The relevant pathways through which the benefits of physical activity are conveyed are also discussed.
AB - The identification of cost-effective interventions that improve the health status and prevent disability in old age is one of the most important public health challenges. Regular physical activity is the only intervention that has consistently been shown to improve functional health and energy balance and to reduce the risk of cardiovascular disease, stroke, diabetes, several cancers, depression and falls. In advanced age, physical activity is also effective at mitigating sarcopenia, restoring robustness, and preventing/delaying the development of disability. On the other hand, physical inactivity is recognized as one of the leading causes of several chronic degenerative diseases and is also a major contributing factor to sarcopenia and functional disability. This compelling evidence has prompted the World Health Organization to recommend engaging in regular physical activity throughout one’s life course. The present review summarizes the available evidence in support of physical activity as a remedy against physical frailty and sarcopenia. The relevant pathways through which the benefits of physical activity are conveyed are also discussed.
KW - Endurance training
KW - Exercise
KW - Physical performance
KW - Resistance training
KW - Skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=85011886923&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011886923&partnerID=8YFLogxK
U2 - 10.1007/s40520-016-0705-4
DO - 10.1007/s40520-016-0705-4
M3 - Article
AN - SCOPUS:85011886923
VL - 29
SP - 35
EP - 42
JO - Aging clinical and experimental research
JF - Aging clinical and experimental research
SN - 1594-0667
IS - 1
ER -