TY - JOUR
T1 - Physical activity and gain in abdominal adiposity and body weight
T2 - Prospective cohort study in 288,498 men and women
AU - Ekelund, Ulf
AU - Besson, Herve
AU - Luan, Jian'an
AU - May, Anne M.
AU - Sharp, Stephen J.
AU - Brage, Søren
AU - Travier, Noemie
AU - Agudo, Antonio
AU - Slimani, Nadia
AU - Rinaldi, Sabina
AU - Jenab, Mazda
AU - Norat, Teresa
AU - Mouw, Traci
AU - Rohrmann, Sabine
AU - Kaaks, Rudolf
AU - Bergmann, Manuela M.
AU - Boeing, Heiner
AU - Clavel-Chapelon, Françoise
AU - Boutron-Ruault, Marie Christine
AU - Overvad, Kim
AU - Jakobsen, Marianne Uhre
AU - Johnsen, Nina Føns
AU - Halkjaer, Jytte
AU - Gonzalez, Carlos A.
AU - Rodriguez, Laudina
AU - Sanchez, Maria José
AU - Arriola, Larraitz
AU - Barricarte, Aurelio
AU - Navarro, Carmen
AU - Key, Timothy J.
AU - Spencer, Elisabeth A.
AU - Orfanos, Philippos
AU - Naska, Androniki
AU - Trichopoulou, Antonia
AU - Manjer, Jonas
AU - Lund, Eiliv
AU - Palli, Dominico
AU - Pala, Valeria
AU - Vineis, Paolo
AU - Mattiello, Amalia
AU - Tumino, Rosario
AU - Bueno-de-Mesquita, H. Bas
AU - Van Den Berg, Saskia W.
AU - Odysseos, Andreani D.
AU - Riboli, Elio
AU - Wareham, Nicolas J.
AU - Peeters, Petra H.
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Background: The protective effect of physical activity (PA) on abdominal adiposity is unclear. Objective: We examined whether PA independently predicted gains in body weight and abdominal adiposity. Design: In a prospective cohort study [the EPIC (European Prospective Investigation into Cancer and Nutrition)], we followed 84,511 men and 203,987 women for 5.1 y. PA was assessed by a validated questionnaire, and individuals were categorized into 4 groups (inactive, moderately inactive, moderately active, and active). Body weight and waist circumference were measured at baseline and self-reported at follow-up. We used multilevel mixed-effects linear regression models and stratified our analyses by sex with adjustments for age, smoking status, alcohol consumption, educational level, total energy intake, duration of follow-up, baseline body weight, change in body weight, and waist circumference (when applicable). Results: PA significantly predicted a lower waist circumference (in cm) in men (β = -0.045; 95% CI: -0.057, -0.034) and in women (β = -0.035; 95% CI: -0.056, -0.015) independent of baseline body weight, baseline waist circumference, and other confounding factors. The magnitude of associations was materially unchanged after adjustment for change in body weight. PA was not significantly associated with annual weight gain (in kg) in men (β = -0.008; 95% CI: -0.02, 0.003) and women (β = -0.01; 95% CI: -0.02, 0.0006). The odds of becoming obese were reduced by 7% (P <0.001) and 10% (P <0.001) for a one-category difference in baseline PA in men and women, respectively. Conclusion: Our results suggest that a higher level of PA reduces abdominal adiposity independent of baseline and changes in body weight and is thus a useful strategy for preventing chronic diseases and premature deaths.
AB - Background: The protective effect of physical activity (PA) on abdominal adiposity is unclear. Objective: We examined whether PA independently predicted gains in body weight and abdominal adiposity. Design: In a prospective cohort study [the EPIC (European Prospective Investigation into Cancer and Nutrition)], we followed 84,511 men and 203,987 women for 5.1 y. PA was assessed by a validated questionnaire, and individuals were categorized into 4 groups (inactive, moderately inactive, moderately active, and active). Body weight and waist circumference were measured at baseline and self-reported at follow-up. We used multilevel mixed-effects linear regression models and stratified our analyses by sex with adjustments for age, smoking status, alcohol consumption, educational level, total energy intake, duration of follow-up, baseline body weight, change in body weight, and waist circumference (when applicable). Results: PA significantly predicted a lower waist circumference (in cm) in men (β = -0.045; 95% CI: -0.057, -0.034) and in women (β = -0.035; 95% CI: -0.056, -0.015) independent of baseline body weight, baseline waist circumference, and other confounding factors. The magnitude of associations was materially unchanged after adjustment for change in body weight. PA was not significantly associated with annual weight gain (in kg) in men (β = -0.008; 95% CI: -0.02, 0.003) and women (β = -0.01; 95% CI: -0.02, 0.0006). The odds of becoming obese were reduced by 7% (P <0.001) and 10% (P <0.001) for a one-category difference in baseline PA in men and women, respectively. Conclusion: Our results suggest that a higher level of PA reduces abdominal adiposity independent of baseline and changes in body weight and is thus a useful strategy for preventing chronic diseases and premature deaths.
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U2 - 10.3945/ajcn.110.006593
DO - 10.3945/ajcn.110.006593
M3 - Article
C2 - 21346093
AN - SCOPUS:79953229545
VL - 93
SP - 826
EP - 835
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 4
ER -