Physical activity and inflammation

Raffaele Di Fenza, Paolo Fiorina

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Diabetes mellitus, referred to simply as diabetes, is a serious metabolic disorder that affects millions of people worldwide [1, 2]. It is caused by defects in insulin production, insulin secretion, and insulin signaling, all of which result in abnormally high blood sugar levels [3]. Diabetes patients usually develop serious secondary complications, especially involving the microvasculature but also cardiovascular disease, retinal damage, nerve damage, and kidney failure [4]. The two principal idiopathic forms of diabetes are known as types 1 and 2. Type 1 diabetes (T1D) is due to an autoimmune attack that leads to self-destruction of the insulin-producing β-cells of the pancreas. Type 2 diabetes (T2D) is caused by defects in insulin action and production, leading to insulin resistance, dyslipidemia, and impaired insulin secretion.

Original languageEnglish
Title of host publicationCellular Physiology and Metabolism of Physical Exercise
PublisherSpringer-Verlag Italia s.r.l.
Pages99-108
Number of pages10
ISBN (Print)9788847024182, 884702417X, 9788847024175
DOIs
Publication statusPublished - Aug 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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