TY - JOUR
T1 - Physical activity and low glycemic index mediterranean diet
T2 - Main and modification effects on NAFLD score. Results from a randomized clinical trial
AU - Franco, Isabella
AU - Bianco, Antonella
AU - Mirizzi, Antonella
AU - Campanella, Angelo
AU - Bonfiglio, Caterina
AU - Sorino, Paolo
AU - Notarnicola, Maria
AU - Tutino, Valeria
AU - Cozzolongo, Raffaele
AU - Giannuzzi, Vito
AU - Aballay, Laura R.
AU - Buongiorno, Claudia
AU - Bruno, Irene
AU - Osella, Alberto R.
N1 - Funding Information:
Funding: This work was supported by RC 2012-2014, Linea 4, C 32 (D.D.n.110/2014) and by Apulia Region D.G.R. n. 1159, 28 June 2018 and 2019.
Publisher Copyright:
© 2020 by the authors. LicenseeMDPI, Basel, Switzerland.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/1
Y1 - 2021/1
N2 - Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease worldwide, and lifestyle modification is the current standard treatment. The aim of the study was to estimate the effect of two different physical activity (PA) programs, a Low Glycemic Index Mediterranean Diet (LGIMD), and their combined effect on the NAFLD score as measured by FibroScan®. Methods: Moderate or severe NAFLD subjects (n = 144) were randomly assigned to six intervention arms during three months. Interventions arms were a control diet, LGIMD, aerobic activity program (PA1), combined activity program (PA2), and LGIMD plus PA1 or LGIMD plus PA2. The data were compared at baseline, at 45 days, and at 90 days. Analysis of variance was performed under the intention-to-treat principle. Results: There was a statistically significant reduction in the NAFLD score after 45 days of treatment in every working arm except for Arm 1 (control diet). After 90 days, the best results were shown by the intervention arms in which LGIMD was associated with PA: LGIMD plus PA1 (-61.56 95% CI -89.61, -33.50) and LGIMD plus PA2 (-38.15 95% CI -64.53, -11.77). Conclusion: All treatments were effective to reduce NAFLD scores, but LGIMD plus PA1 was the most efficient.
AB - Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease worldwide, and lifestyle modification is the current standard treatment. The aim of the study was to estimate the effect of two different physical activity (PA) programs, a Low Glycemic Index Mediterranean Diet (LGIMD), and their combined effect on the NAFLD score as measured by FibroScan®. Methods: Moderate or severe NAFLD subjects (n = 144) were randomly assigned to six intervention arms during three months. Interventions arms were a control diet, LGIMD, aerobic activity program (PA1), combined activity program (PA2), and LGIMD plus PA1 or LGIMD plus PA2. The data were compared at baseline, at 45 days, and at 90 days. Analysis of variance was performed under the intention-to-treat principle. Results: There was a statistically significant reduction in the NAFLD score after 45 days of treatment in every working arm except for Arm 1 (control diet). After 90 days, the best results were shown by the intervention arms in which LGIMD was associated with PA: LGIMD plus PA1 (-61.56 95% CI -89.61, -33.50) and LGIMD plus PA2 (-38.15 95% CI -64.53, -11.77). Conclusion: All treatments were effective to reduce NAFLD scores, but LGIMD plus PA1 was the most efficient.
KW - Aerobic exercise
KW - Combined exercise
KW - Controlled attenuation parameter (CAP)
KW - Diet
KW - Non-alcoholic fatty liver disease
KW - Physical activity
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U2 - 10.3390/nu13010066
DO - 10.3390/nu13010066
M3 - Article
C2 - 33379253
AN - SCOPUS:85099238454
VL - 13
SP - 1
EP - 24
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 1
M1 - 66
ER -