TY - JOUR
T1 - Physical activity and risk of endometrial cancer
T2 - The European prospective investigation into cancer and nutrition
AU - Friedenreich, Christine
AU - Cust, Anne
AU - Lahmann, Petra H.
AU - Steindorf, Karen
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Françoise
AU - Mesrine, Sylvie
AU - Linseisen, Jakob
AU - Rohrmann, Sabine
AU - Pischon, Tobias
AU - Schulz, Mandy
AU - Tjønneland, Anne
AU - Johnsen, Nina Fons
AU - Overvad, Kim
AU - Mendez, Michelle
AU - Arguelles, M. V.
AU - Garcia, Carmen Martinez
AU - Larrañaga, Nerea
AU - Chirlaque, Maria Dolores
AU - Ardanaz, Eva
AU - Bingham, Sheila
AU - Khaw, Kay Tee
AU - Allen, Naomi
AU - Key, Tim
AU - Trichopoulou, Antonia
AU - Dilis, Vardis
AU - Trichopoulos, Dimitrios
AU - Pala, Valeria
AU - Palli, Domenico
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Vineis, Paolo
AU - Bueno-de-Mesquita, H. Bas
AU - Peeters, Petra H M
AU - Monninkhof, Evelyn
AU - Berglund, Göran
AU - Manjer, Jonas
AU - Slimani, Nadia
AU - Ferrari, Pietro
AU - Kaaks, Rudolf
AU - Riboli, Elio
PY - 2007/7/15
Y1 - 2007/7/15
N2 - The etiologic role of physical activity in endometrial cancer risk remains unclear given the few epidemiologic studies that have been conducted. To investigate this relation more fully, an analysis was undertaken in the European prospective investigation into cancer and nutrition (EPIC). During an average 6.6 years of follow-up, 689 incident endometrial cancer cases were identified from an analytic cohort within EPIC of 253,023 women. Cox proportional hazards models were used to estimate the associations between type of activity (total, occupational, household, recreational) and endometrial cancer risk. For total activity, women in the highest compared with the lowest quartile of activity had a risk of 0.88 (95% confidence interval (95% CI = 0.61-1.27). No clear associations between each type of activity and endometrial cancer risk were found for the total study population combined. Associations were more evident in the stratified results, with premenopausal women who were active versus inactive experiencing a risk of 0.66 (95% CI = 0.38-1.14) overall. Among premenopausal women, for household and recreational activities the risk estimates in the highest as compared with the lowest quartiles were, respectively, 0.48 (95% CI = 0.23-0.99) and 0.78 (95% CI = 0.44-1.39). No effect modification by body mass index, hormone replacement therapy, oral contraceptive use or energy intake was found. This study provides no evidence of a protective effect of increased physical activity in endometrial cancer risk in all women but some support for a benefit among premenopausal women. The relative risk reductions are most apparent for household activities.
AB - The etiologic role of physical activity in endometrial cancer risk remains unclear given the few epidemiologic studies that have been conducted. To investigate this relation more fully, an analysis was undertaken in the European prospective investigation into cancer and nutrition (EPIC). During an average 6.6 years of follow-up, 689 incident endometrial cancer cases were identified from an analytic cohort within EPIC of 253,023 women. Cox proportional hazards models were used to estimate the associations between type of activity (total, occupational, household, recreational) and endometrial cancer risk. For total activity, women in the highest compared with the lowest quartile of activity had a risk of 0.88 (95% confidence interval (95% CI = 0.61-1.27). No clear associations between each type of activity and endometrial cancer risk were found for the total study population combined. Associations were more evident in the stratified results, with premenopausal women who were active versus inactive experiencing a risk of 0.66 (95% CI = 0.38-1.14) overall. Among premenopausal women, for household and recreational activities the risk estimates in the highest as compared with the lowest quartiles were, respectively, 0.48 (95% CI = 0.23-0.99) and 0.78 (95% CI = 0.44-1.39). No effect modification by body mass index, hormone replacement therapy, oral contraceptive use or energy intake was found. This study provides no evidence of a protective effect of increased physical activity in endometrial cancer risk in all women but some support for a benefit among premenopausal women. The relative risk reductions are most apparent for household activities.
KW - Biologic mechanisms
KW - Endometrial cancer
KW - Etiology
KW - Physical activity
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U2 - 10.1002/ijc.22676
DO - 10.1002/ijc.22676
M3 - Article
C2 - 17357139
AN - SCOPUS:34250313242
VL - 121
SP - 347
EP - 355
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 2
ER -