Physical activity and risk of endometrial cancer: The European prospective investigation into cancer and nutrition

Christine Friedenreich, Anne Cust, Petra H. Lahmann, Karen Steindorf, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Sylvie Mesrine, Jakob Linseisen, Sabine Rohrmann, Tobias Pischon, Mandy Schulz, Anne Tjønneland, Nina Fons Johnsen, Kim Overvad, Michelle Mendez, M. V. Arguelles, Carmen Martinez Garcia, Nerea Larrañaga, Maria Dolores Chirlaque, Eva ArdanazSheila Bingham, Kay Tee Khaw, Naomi Allen, Tim Key, Antonia Trichopoulou, Vardis Dilis, Dimitrios Trichopoulos, Valeria Pala, Domenico Palli, Rosario Tumino, Salvatore Panico, Paolo Vineis, H. Bas Bueno-de-Mesquita, Petra H M Peeters, Evelyn Monninkhof, Göran Berglund, Jonas Manjer, Nadia Slimani, Pietro Ferrari, Rudolf Kaaks, Elio Riboli

Research output: Contribution to journalArticlepeer-review


The etiologic role of physical activity in endometrial cancer risk remains unclear given the few epidemiologic studies that have been conducted. To investigate this relation more fully, an analysis was undertaken in the European prospective investigation into cancer and nutrition (EPIC). During an average 6.6 years of follow-up, 689 incident endometrial cancer cases were identified from an analytic cohort within EPIC of 253,023 women. Cox proportional hazards models were used to estimate the associations between type of activity (total, occupational, household, recreational) and endometrial cancer risk. For total activity, women in the highest compared with the lowest quartile of activity had a risk of 0.88 (95% confidence interval (95% CI = 0.61-1.27). No clear associations between each type of activity and endometrial cancer risk were found for the total study population combined. Associations were more evident in the stratified results, with premenopausal women who were active versus inactive experiencing a risk of 0.66 (95% CI = 0.38-1.14) overall. Among premenopausal women, for household and recreational activities the risk estimates in the highest as compared with the lowest quartiles were, respectively, 0.48 (95% CI = 0.23-0.99) and 0.78 (95% CI = 0.44-1.39). No effect modification by body mass index, hormone replacement therapy, oral contraceptive use or energy intake was found. This study provides no evidence of a protective effect of increased physical activity in endometrial cancer risk in all women but some support for a benefit among premenopausal women. The relative risk reductions are most apparent for household activities.

Original languageEnglish
Pages (from-to)347-355
Number of pages9
JournalInternational Journal of Cancer
Issue number2
Publication statusPublished - Jul 15 2007


  • Biologic mechanisms
  • Endometrial cancer
  • Etiology
  • Physical activity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


Dive into the research topics of 'Physical activity and risk of endometrial cancer: The European prospective investigation into cancer and nutrition'. Together they form a unique fingerprint.

Cite this