Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.

Nikos Papadimitriou; Niki Dimou; Konstantinos K. Tsilidis; Barbara Banbury; Richard M. Martin; Sarah J. Lewis; Nabila Kazmi; Timothy M. Robinson; Demetrius Albanes; Krasimira Aleksandrova; Sonja I. Berndt; D. Timothy Bishop; Hermann Brenner; Daniel D. Buchanan; Bas Bueno-de-Mesquita; Peter T. Campbell; Sergi Castellví-Bel; Andrew T. Chan; Jenny Chang-Claude; Merete Ellingjord-Dale; Jane C. Figueiredo; Steven J. Gallinger; Graham G. Giles; Edward Giovannucci; Stephen B. Gruber; Andrea Gsur; Jochen Hampe; Heather Hampel; Sophia Harlid; Tabitha A. Harrison; Michael Hoffmeister; John L. Hopper; Li Hsu; José María Huerta; Jeroen R. Huyghe; Mark A. Jenkins; Temitope O. Keku; Tilman Kühn; Carlo La Vecchia; Loic Le Marchand; Christopher I. Li; Li Li; Annika Lindblom; Noralane M. Lindor; Brigid Lynch; Sanford D. Markowitz; Giovanna Masala; Anne M. May; Roger Milne; Evelyn Monninkhof; Lorena Moreno; Victor Moreno; Polly A. Newcomb; Kenneth Offit; Vittorio Perduca; Paul D. P. Pharoah; Elizabeth A. Platz; John D. Potter; Gad Rennert; Elio Riboli; Maria-Jose Sánchez; Stephanie L. Schmit; Robert E. Schoen; Gianluca Severi; Sabina Sieri; Martha L. Slattery; Mingyang Song; Catherine M. Tangen; Stephen N. Thibodeau; Ruth C. Travis; Antonia Trichopoulou; Cornelia M. Ulrich; Franzel J. B. van Duijnhoven; Bethany Van Guelpen; Pavel Vodicka; Emily White; Alicja Wolk; Michael O. Woods; Anna H. Wu; Ulrike Peters; Marc J. Gunter; Neil Murphy

doi:10.1038/s41467-020-14389-8

Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.

Nikos Papadimitriou, Niki Dimou, Konstantinos K. Tsilidis, Barbara Banbury, Richard M. Martin, Sarah J. Lewis, Nabila Kazmi, Timothy M. Robinson, Demetrius Albanes, Krasimira Aleksandrova, Sonja I. Berndt, D. Timothy Bishop, Hermann Brenner, Daniel D. Buchanan, Bas Bueno-de-Mesquita, Peter T. Campbell, Sergi Castellví-Bel, Andrew T. Chan, Jenny Chang-Claude, Merete Ellingjord-DaleJane C. Figueiredo, Steven J. Gallinger, Graham G. Giles, Edward Giovannucci, Stephen B. Gruber, Andrea Gsur, Jochen Hampe, Heather Hampel, Sophia Harlid, Tabitha A. Harrison, Michael Hoffmeister, John L. Hopper, Li Hsu, José María Huerta, Jeroen R. Huyghe, Mark A. Jenkins, Temitope O. Keku, Tilman Kühn, Carlo La Vecchia, Loic Le Marchand, Christopher I. Li, Li Li, Annika Lindblom, Noralane M. Lindor, Brigid Lynch, Sanford D. Markowitz, Giovanna Masala, Anne M. May, Roger Milne, Evelyn Monninkhof, Lorena Moreno, Victor Moreno, Polly A. Newcomb, Kenneth Offit, Vittorio Perduca, Paul D. P. Pharoah, Elizabeth A. Platz, John D. Potter, Gad Rennert, Elio Riboli, Maria-Jose Sánchez, Stephanie L. Schmit, Robert E. Schoen, Gianluca Severi, Sabina Sieri, Martha L. Slattery, Mingyang Song, Catherine M. Tangen, Stephen N. Thibodeau, Ruth C. Travis, Antonia Trichopoulou, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Pavel Vodicka, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Ulrike Peters, Marc J. Gunter, Neil Murphy

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER(+ve)) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

Original language	English
Pages (from-to)	597
Number of pages	1
Journal	Nat. Commun.
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-14389-8
Publication status	Published - Jan 1 2020

Keywords

Female
Humans
Risk Factors
Odds Ratio
Accelerometry
*Exercise
*Genetic Predisposition to Disease
*Mendelian Randomization Analysis
Breast Neoplasms/*genetics
Colorectal Neoplasms/*genetics
Polymorphism
Single Nucleotide/genetics

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Papadimitriou, N., Dimou, N., Tsilidis, K. K., Banbury, B., Martin, R. M., Lewis, S. J., Kazmi, N., Robinson, T. M., Albanes, D., Aleksandrova, K., Berndt, S. I., Timothy Bishop, D., Brenner, H., Buchanan, D. D., Bueno-de-Mesquita, B., Campbell, P. T., Castellví-Bel, S., Chan, A. T., Chang-Claude, J., ... Murphy, N. (2020). Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. Nat. Commun., 11(1), 597. https://doi.org/10.1038/s41467-020-14389-8

Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. / Papadimitriou, Nikos; Dimou, Niki; Tsilidis, Konstantinos K.; Banbury, Barbara; Martin, Richard M.; Lewis, Sarah J.; Kazmi, Nabila; Robinson, Timothy M.; Albanes, Demetrius; Aleksandrova, Krasimira; Berndt, Sonja I.; Timothy Bishop, D.; Brenner, Hermann; Buchanan, Daniel D.; Bueno-de-Mesquita, Bas; Campbell, Peter T.; Castellví-Bel, Sergi; Chan, Andrew T.; Chang-Claude, Jenny; Ellingjord-Dale, Merete; Figueiredo, Jane C.; Gallinger, Steven J.; Giles, Graham G.; Giovannucci, Edward; Gruber, Stephen B.; Gsur, Andrea; Hampe, Jochen; Hampel, Heather; Harlid, Sophia; Harrison, Tabitha A.; Hoffmeister, Michael; Hopper, John L.; Hsu, Li; María Huerta, José; Huyghe, Jeroen R.; Jenkins, Mark A.; Keku, Temitope O.; Kühn, Tilman; La Vecchia, Carlo; Le Marchand, Loic; Li, Christopher I.; Li, Li; Lindblom, Annika; Lindor, Noralane M.; Lynch, Brigid; Markowitz, Sanford D.; Masala, Giovanna; May, Anne M.; Milne, Roger; Monninkhof, Evelyn; Moreno, Lorena; Moreno, Victor; Newcomb, Polly A.; Offit, Kenneth; Perduca, Vittorio; Pharoah, Paul D. P.; Platz, Elizabeth A.; Potter, John D.; Rennert, Gad; Riboli, Elio; Sánchez, Maria-Jose; Schmit, Stephanie L.; Schoen, Robert E.; Severi, Gianluca; Sieri, Sabina; Slattery, Martha L.; Song, Mingyang; Tangen, Catherine M.; Thibodeau, Stephen N.; Travis, Ruth C.; Trichopoulou, Antonia; Ulrich, Cornelia M.; van Duijnhoven, Franzel J. B.; Van Guelpen, Bethany; Vodicka, Pavel; White, Emily; Wolk, Alicja; Woods, Michael O.; Wu, Anna H.; Peters, Ulrike; Gunter, Marc J.; Murphy, Neil.

In: Nat. Commun., Vol. 11, No. 1, 01.01.2020, p. 597.

Research output: Contribution to journal › Article › peer-review

Papadimitriou, N, Dimou, N, Tsilidis, KK, Banbury, B, Martin, RM, Lewis, SJ, Kazmi, N, Robinson, TM, Albanes, D, Aleksandrova, K, Berndt, SI, Timothy Bishop, D, Brenner, H, Buchanan, DD, Bueno-de-Mesquita, B, Campbell, PT, Castellví-Bel, S, Chan, AT, Chang-Claude, J, Ellingjord-Dale, M, Figueiredo, JC, Gallinger, SJ, Giles, GG, Giovannucci, E, Gruber, SB, Gsur, A, Hampe, J, Hampel, H, Harlid, S, Harrison, TA, Hoffmeister, M, Hopper, JL, Hsu, L, María Huerta, J, Huyghe, JR, Jenkins, MA, Keku, TO, Kühn, T, La Vecchia, C, Le Marchand, L, Li, CI, Li, L, Lindblom, A, Lindor, NM, Lynch, B, Markowitz, SD, Masala, G, May, AM, Milne, R, Monninkhof, E, Moreno, L, Moreno, V, Newcomb, PA, Offit, K, Perduca, V, Pharoah, PDP, Platz, EA, Potter, JD, Rennert, G, Riboli, E, Sánchez, M-J, Schmit, SL, Schoen, RE, Severi, G, Sieri, S, Slattery, ML, Song, M, Tangen, CM, Thibodeau, SN, Travis, RC, Trichopoulou, A, Ulrich, CM, van Duijnhoven, FJB, Van Guelpen, B, Vodicka, P, White, E, Wolk, A, Woods, MO, Wu, AH, Peters, U, Gunter, MJ & Murphy, N 2020, 'Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.', Nat. Commun., vol. 11, no. 1, pp. 597. https://doi.org/10.1038/s41467-020-14389-8

Papadimitriou, Nikos ; Dimou, Niki ; Tsilidis, Konstantinos K. ; Banbury, Barbara ; Martin, Richard M. ; Lewis, Sarah J. ; Kazmi, Nabila ; Robinson, Timothy M. ; Albanes, Demetrius ; Aleksandrova, Krasimira ; Berndt, Sonja I. ; Timothy Bishop, D. ; Brenner, Hermann ; Buchanan, Daniel D. ; Bueno-de-Mesquita, Bas ; Campbell, Peter T. ; Castellví-Bel, Sergi ; Chan, Andrew T. ; Chang-Claude, Jenny ; Ellingjord-Dale, Merete ; Figueiredo, Jane C. ; Gallinger, Steven J. ; Giles, Graham G. ; Giovannucci, Edward ; Gruber, Stephen B. ; Gsur, Andrea ; Hampe, Jochen ; Hampel, Heather ; Harlid, Sophia ; Harrison, Tabitha A. ; Hoffmeister, Michael ; Hopper, John L. ; Hsu, Li ; María Huerta, José ; Huyghe, Jeroen R. ; Jenkins, Mark A. ; Keku, Temitope O. ; Kühn, Tilman ; La Vecchia, Carlo ; Le Marchand, Loic ; Li, Christopher I. ; Li, Li ; Lindblom, Annika ; Lindor, Noralane M. ; Lynch, Brigid ; Markowitz, Sanford D. ; Masala, Giovanna ; May, Anne M. ; Milne, Roger ; Monninkhof, Evelyn ; Moreno, Lorena ; Moreno, Victor ; Newcomb, Polly A. ; Offit, Kenneth ; Perduca, Vittorio ; Pharoah, Paul D. P. ; Platz, Elizabeth A. ; Potter, John D. ; Rennert, Gad ; Riboli, Elio ; Sánchez, Maria-Jose ; Schmit, Stephanie L. ; Schoen, Robert E. ; Severi, Gianluca ; Sieri, Sabina ; Slattery, Martha L. ; Song, Mingyang ; Tangen, Catherine M. ; Thibodeau, Stephen N. ; Travis, Ruth C. ; Trichopoulou, Antonia ; Ulrich, Cornelia M. ; van Duijnhoven, Franzel J. B. ; Van Guelpen, Bethany ; Vodicka, Pavel ; White, Emily ; Wolk, Alicja ; Woods, Michael O. ; Wu, Anna H. ; Peters, Ulrike ; Gunter, Marc J. ; Murphy, Neil. / Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. In: Nat. Commun. 2020 ; Vol. 11, No. 1. pp. 597.

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abstract = "Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER(+ve)) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.",

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AU - Papadimitriou, Nikos

AU - Dimou, Niki

AU - Tsilidis, Konstantinos K.

AU - Banbury, Barbara

AU - Martin, Richard M.

AU - Lewis, Sarah J.

AU - Kazmi, Nabila

AU - Robinson, Timothy M.

AU - Albanes, Demetrius

AU - Aleksandrova, Krasimira

AU - Berndt, Sonja I.

AU - Timothy Bishop, D.

AU - Brenner, Hermann

AU - Buchanan, Daniel D.

AU - Bueno-de-Mesquita, Bas

AU - Campbell, Peter T.

AU - Castellví-Bel, Sergi

AU - Chan, Andrew T.

AU - Chang-Claude, Jenny

AU - Ellingjord-Dale, Merete

AU - Figueiredo, Jane C.

AU - Gallinger, Steven J.

AU - Giles, Graham G.

AU - Giovannucci, Edward

AU - Gruber, Stephen B.

AU - Gsur, Andrea

AU - Hampe, Jochen

AU - Hampel, Heather

AU - Harlid, Sophia

AU - Harrison, Tabitha A.

AU - Hoffmeister, Michael

AU - Hopper, John L.

AU - Hsu, Li

AU - María Huerta, José

AU - Huyghe, Jeroen R.

AU - Jenkins, Mark A.

AU - Keku, Temitope O.

AU - Kühn, Tilman

AU - La Vecchia, Carlo

AU - Le Marchand, Loic

AU - Li, Christopher I.

AU - Li, Li

AU - Lindblom, Annika

AU - Lindor, Noralane M.

AU - Lynch, Brigid

AU - Markowitz, Sanford D.

AU - Masala, Giovanna

AU - May, Anne M.

AU - Milne, Roger

AU - Monninkhof, Evelyn

AU - Moreno, Lorena

AU - Moreno, Victor

AU - Newcomb, Polly A.

AU - Offit, Kenneth

AU - Perduca, Vittorio

AU - Pharoah, Paul D. P.

AU - Platz, Elizabeth A.

AU - Potter, John D.

AU - Rennert, Gad

AU - Riboli, Elio

AU - Sánchez, Maria-Jose

AU - Schmit, Stephanie L.

AU - Schoen, Robert E.

AU - Severi, Gianluca

AU - Sieri, Sabina

AU - Slattery, Martha L.

AU - Song, Mingyang

AU - Tangen, Catherine M.

AU - Thibodeau, Stephen N.

AU - Travis, Ruth C.

AU - Trichopoulou, Antonia

AU - Ulrich, Cornelia M.

AU - van Duijnhoven, Franzel J. B.

AU - Van Guelpen, Bethany

AU - Vodicka, Pavel

AU - White, Emily

AU - Wolk, Alicja

AU - Woods, Michael O.

AU - Wu, Anna H.

AU - Peters, Ulrike

AU - Gunter, Marc J.

AU - Murphy, Neil

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER(+ve)) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

AB - Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER(+ve)) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

KW - Female

KW - Humans

KW - Risk Factors

KW - Odds Ratio

KW - Accelerometry

KW - Exercise

KW - Genetic Predisposition to Disease

KW - Mendelian Randomization Analysis

KW - Breast Neoplasms/genetics

KW - Colorectal Neoplasms/genetics

KW - Polymorphism

KW - Single Nucleotide/genetics

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DO - 10.1038/s41467-020-14389-8

M3 - Article

VL - 11

SP - 597

JO - Nat. Commun.

JF - Nat. Commun.

SN - 2041-1723

IS - 1

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