Physical activity during leisure time and primary prevention of coronary heart disease: An updated meta-analysis of cohort studies

Francesco Sofi, Andrea Capalbo, Francesca Cesari, Rosanna Abbate, Gian Franco Gensini

Research output: Contribution to journalArticle

Abstract

BACKGROUND: A vast body of evidence during the last decades has shown the clear preventive role of physical activity in cardiovascular disease. The real magnitude of the association between physical activity during leisure time (LTPA) and primary prevention of coronary heart disease (CHD) has, however, not been completely defined. DESIGN: Meta-analysis of prospective cohort studies. METHODS: Studies were included if they reported relative risks and their corresponding 95% confidence intervals (CI), for categories of LTPA in relation to CHD. The LTPA categories of the selected studies were grouped into three levels of intensity: high, moderate and low. The high level of physical activity was determined, to obtain a level of intensity attainable by the general population. RESULTS: Data were available for 26 studies, incorporating 513 472 individuals (20 666 CHD events), followed up for 4-25 years. Under a random-effects model, the overall analysis showed that individuals who reported performing a high level of LTPA had significant protection against CHD [relative risk 0.73 (95% CI 0.66-0.80), P

Original languageEnglish
Pages (from-to)247-257
Number of pages11
JournalEuropean Journal of Cardiovascular Prevention and Rehabilitation
Volume15
Issue number3
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Cardiovascular disease
  • Coronary heart disease
  • Exercise
  • Meta-analysis
  • Physical activity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Epidemiology

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