Physical rehabilitation has a positive effect on disability in multiple sclerosis patients

Alessandra Solari, G. Filippini, P. Gasco, L. Colla, A. Salmaggi, L. La Mantia, M. Farinotti, M. Eoli, L. Mendozzi

Research output: Contribution to journalArticle

208 Citations (Scopus)

Abstract

Background: Although physical rehabilitation is commonly administered to MS patients, its efficacy has not been established. Objective: We assessed the efficacy of an inpatient physical rehabilitation program on impairment, disability, and quality of life of MS patients with a randomized, single- blind, controlled trial. Methods: Fifty ambulatory MS patients were assigned to 3 weeks of inpatient physical rehabilitation (study treatment) or exercises performed at home (control treatment). Patients were evaluated at baseline and at 3, 9, and 15 weeks by a blinded examining physician. Results: No changes in impairment occurred in either group, as measured by the Expanded Disability Status Scale. At the end of the intervention the study group improved significantly in disability, as assessed by the Functional Independence Measure (FIM) motor domain, compared with controls (p = 0.004), and the improvement persisted at 9 weeks (p = 0.001). The effect size statistic was usually large or moderate in all scale scores of the FIM motor domain at 3 weeks and moderate to fair thereafter. The study group also improved in overall health-related quality of life profile compared with controls; however, the difference was significant only for the mental Composite Score at 3 (p = 0.008) and 9 weeks (p = 0.001). Conclusions: Despite unchanging impairment, physical rehabilitation resulted in an improvement in disability and had a positive impact on mental components of health-related quality of life perception at 3 and 9 weeks.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalNeurology
Volume52
Issue number1
Publication statusPublished - Jan 1 1999

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Multiple Sclerosis
Rehabilitation
Quality of Life
Inpatients
Mental Health
Exercise
Physicians
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Solari, A., Filippini, G., Gasco, P., Colla, L., Salmaggi, A., La Mantia, L., ... Mendozzi, L. (1999). Physical rehabilitation has a positive effect on disability in multiple sclerosis patients. Neurology, 52(1), 57-62.

Physical rehabilitation has a positive effect on disability in multiple sclerosis patients. / Solari, Alessandra; Filippini, G.; Gasco, P.; Colla, L.; Salmaggi, A.; La Mantia, L.; Farinotti, M.; Eoli, M.; Mendozzi, L.

In: Neurology, Vol. 52, No. 1, 01.01.1999, p. 57-62.

Research output: Contribution to journalArticle

Solari, A, Filippini, G, Gasco, P, Colla, L, Salmaggi, A, La Mantia, L, Farinotti, M, Eoli, M & Mendozzi, L 1999, 'Physical rehabilitation has a positive effect on disability in multiple sclerosis patients', Neurology, vol. 52, no. 1, pp. 57-62.
Solari A, Filippini G, Gasco P, Colla L, Salmaggi A, La Mantia L et al. Physical rehabilitation has a positive effect on disability in multiple sclerosis patients. Neurology. 1999 Jan 1;52(1):57-62.
Solari, Alessandra ; Filippini, G. ; Gasco, P. ; Colla, L. ; Salmaggi, A. ; La Mantia, L. ; Farinotti, M. ; Eoli, M. ; Mendozzi, L. / Physical rehabilitation has a positive effect on disability in multiple sclerosis patients. In: Neurology. 1999 ; Vol. 52, No. 1. pp. 57-62.
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