Physical training enhances sympathetic and parasympathetic control of heart rate and peripheral vessels in chronic heart failure

A. Radaelli, A. J S Coats, S. Leuzzi, M. Piepoli, T. E. Meyer, A. Calciati, G. Finardi, L. Bernardi, P. Sleight

Research output: Contribution to journalArticlepeer-review

Abstract

1. Physical training has been proposed to increase vagal control of heart rate in chronic heart failure. We studied the effects of physical training on cardiovascular control in 6 moderate to severe heart failure (NYHA II-III) patients and 6 age matched normal controls in a randomized controlled cross over trial (Training vs Detraining). 2. Five weeks training (20 min/day, 5 days/week bicycle exercise) increased peak VO2 in both C (from 31.2 ± 1.4 to 37.7 ± 2.4 ml/kg/min p <0.01) and CHF patients (from 12.16 ± 2.2 to 14.13 ± 2 ml/kg/min p <0.05). The sympathovagal control of heart rate and sympathetic control of the resistance vessels was assessed by the power of the oscillations (LF: 0.03-0.15 Hz index of sympathetic activity, HF: 0.18-0.35 Hz index of vagal activity) in RR interval, blood pressure (systolic and diastolic by Finapres) and respiration by autoregressive spectral analysis, during free and controlled breathing (15 b/min), in order to increase vagal activity. 3. T increased heart rate vagal control both in C (LF/HF ratio fb to cb: (D) 1.73 ± 0.35 to 1.19 ± 0.43 p = NS: (T) 2.9 ± 1.2 to 1.13 ± 0.3 p <0.05) and in CHF patients (LF/HF ratio fb to cb: (D) 2.05 ± 0.56 to 1.24 ± 0.21 p = NS; (T) 2.6 ± 0.89 to 0.87 ± 0.15 p <0.05; and in cb HF%: 36.2 ± 2.7 (D) to 46.2 ± 4.8 (T) p <0.05). Before T, the sympathetic modulation of peripheral vessels (% LF compared to total variability) was depressed in CHF vs C (SBP: 9 ± 2 vs 42 ± 12% p <0.05; DBP: 29 ± 7 vs 55 ± 31%, p <0.05), and increased significantly after T in CHF (SBP from 9 ± 2 (D) to 19 ± 5% (T) p <0.05; DBP from 29 ± 7 to 41 ± 11% (T) p <0.05). This suggests an overall increase of autonomic control, both vagal on the heart and sympathetic on the peripheral vessels, in CHF by physical training.

Original languageEnglish
Pages (from-to)92-94
Number of pages3
JournalClinical Science
Volume91
Issue number1 SUPPL.
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Medicine(all)

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