Abstract
Several studies suggest that the modification of a titanium surface could play an important role in bone tissue engineering. In this study we have followed a biomimetic strategy where ultrasonically or electromagnetically stimulated human SAOS-2 osteoblasts proliferated and built their extracellular matrix on a titanium plasma-spray surface. In comparison with control conditions, the ultrasonic stimulus (power, 149 mW; frequency, 1.5 MHz) and the electromagnetic stimulus (magnetic field, 2 mT; frequency, 75 Hz) increased the cell proliferation and the surface coating with type-I collagen. The physical stimuli aimed at obtaining a better modification of the rough titanium plasma-spray surface in terms of cell colonization and coating with bone matrix. The superficially modified biomaterial could be used, in clinical applications, as an implant for bone repair.
| Original language | English |
|---|---|
| Title of host publication | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Pages | 6414-6417 |
| Number of pages | 4 |
| DOIs | |
| Publication status | Published - 2007 |
| Event | 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 - Lyon, France Duration: Aug 23 2007 → Aug 26 2007 |
Other
| Other | 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 |
|---|---|
| Country | France |
| City | Lyon |
| Period | 8/23/07 → 8/26/07 |
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ASJC Scopus subject areas
- Biomedical Engineering
Cite this
Physically enhanced coating of a titanium plasma-spray surface with human SAOS-2 osteoblasts and extracellular matrix. / Fassina, Lorenzo; Saino, Enrica; Visai, Livia; Magenes, Giovanni.
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. p. 6414-6417 4353824.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Physically enhanced coating of a titanium plasma-spray surface with human SAOS-2 osteoblasts and extracellular matrix
AU - Fassina, Lorenzo
AU - Saino, Enrica
AU - Visai, Livia
AU - Magenes, Giovanni
PY - 2007
Y1 - 2007
N2 - Several studies suggest that the modification of a titanium surface could play an important role in bone tissue engineering. In this study we have followed a biomimetic strategy where ultrasonically or electromagnetically stimulated human SAOS-2 osteoblasts proliferated and built their extracellular matrix on a titanium plasma-spray surface. In comparison with control conditions, the ultrasonic stimulus (power, 149 mW; frequency, 1.5 MHz) and the electromagnetic stimulus (magnetic field, 2 mT; frequency, 75 Hz) increased the cell proliferation and the surface coating with type-I collagen. The physical stimuli aimed at obtaining a better modification of the rough titanium plasma-spray surface in terms of cell colonization and coating with bone matrix. The superficially modified biomaterial could be used, in clinical applications, as an implant for bone repair.
AB - Several studies suggest that the modification of a titanium surface could play an important role in bone tissue engineering. In this study we have followed a biomimetic strategy where ultrasonically or electromagnetically stimulated human SAOS-2 osteoblasts proliferated and built their extracellular matrix on a titanium plasma-spray surface. In comparison with control conditions, the ultrasonic stimulus (power, 149 mW; frequency, 1.5 MHz) and the electromagnetic stimulus (magnetic field, 2 mT; frequency, 75 Hz) increased the cell proliferation and the surface coating with type-I collagen. The physical stimuli aimed at obtaining a better modification of the rough titanium plasma-spray surface in terms of cell colonization and coating with bone matrix. The superficially modified biomaterial could be used, in clinical applications, as an implant for bone repair.
UR - http://www.scopus.com/inward/record.url?scp=57649193090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57649193090&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2007.4353824
DO - 10.1109/IEMBS.2007.4353824
M3 - Conference contribution
AN - SCOPUS:57649193090
SN - 1424407885
SN - 9781424407880
SP - 6414
EP - 6417
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ER -