Physician-initiated prospective Italian Registry of carotid stenting with the C-Guard mesh-stent: The IRON-Guard registry. Rationale and design

C. Setacci, F. Speziale, G. De Donato, P. Sirignano, F. Setacci, L. Capoccia, G. Galzerano, W. Mansour, Carlo Setacci, Francesco Speziale, Guido Bellandi, Piergiorgio Cao, Renato Casana, Patrizio Castelli, Roberto Chiesa, Gioachino Coppi, Alberto Cremonesi, Gianfranco Fadda, Augusto Farina, Paolo FrigattiAndrea Gaggiano, Franco Grego, Massimo Lenti, Nicola Mangialardi, Giustino Marcucci, Stefano Michelagnoli, Giovanni Nano, Franco Nessi, Claudio Novali, Giancarlo Palasciano, Domenico Palombo, Giovanni Paroni, Francesco Pompeo, Claudio Rabbia, Massimo Sponza, Andrea Stella, Enrico Vecchiati

Research output: Contribution to journalArticle

Abstract

According to the World Health Organization, every year, 5 million peoples die for stroke and another 5 million are permanently disabled. Although there are many causes of acute stroke, a common treatable cause of acute stroke is atheromatous narrowing at the carotid bifurcation. Carotid endarterectomy is still the standard of car, even if carotid artery stenting (CAS) has become an effective, less invasive alterantive. Unfortunately, CAS procedure is not yet perfect; regardless the use of an embolic protection device (EPD), percutaneous treatment has been correlated with a risk of cerebral ischemic events related to distal embolization. The objective of the IRON-Guard Registry is to evaluate the clinical outcome of treatment by means of stenting with the C-Guard (InspireMD, Boston, MA, USA) in subjects requiring CAS due to significant extracranial carotid artery stenosis with a physician-initiated, Italian, prospective, multicenter, single-arm study. A total of 200 enrolled subjects divided over different centers are planned to be enrolled. CAS will performed by implanting of C-Guard stent. Procedure will be performed according to the physician's standard of care. Standard procedures will be followed based on the Instructions for Use, for the C-Guard device of Inspire. The primary endpoint of this study is the 30-day rate of major adverse events (MAE), defined as the cumulative incidence of any periprocedural (≤30 days postprocedure) death, stroke or myocardial infarction. Secondary endpoints are rate of late ipsilateral stroke (31 through 365 days), system technical success, device malfunctions, major adverse events (MAEs), serious device-related and procedure-related adverse events, target lesion revascularization, and in-stent restenosis rates.

Original languageEnglish
Pages (from-to)787-791
Number of pages5
JournalJournal of Cardiovascular Surgery
Volume56
Issue number5
Publication statusPublished - Oct 1 2015

Keywords

  • Embolization
  • Stents
  • Stroke
  • Therapeutic

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Medicine(all)

Fingerprint Dive into the research topics of 'Physician-initiated prospective Italian Registry of carotid stenting with the C-Guard mesh-stent: The IRON-Guard registry. Rationale and design'. Together they form a unique fingerprint.

  • Cite this

    Setacci, C., Speziale, F., De Donato, G., Sirignano, P., Setacci, F., Capoccia, L., Galzerano, G., Mansour, W., Setacci, C., Speziale, F., Bellandi, G., Cao, P., Casana, R., Castelli, P., Chiesa, R., Coppi, G., Cremonesi, A., Fadda, G., Farina, A., ... Vecchiati, E. (2015). Physician-initiated prospective Italian Registry of carotid stenting with the C-Guard mesh-stent: The IRON-Guard registry. Rationale and design. Journal of Cardiovascular Surgery, 56(5), 787-791.