Physico-chemical characterization and dissolution properties of nifluminic acid-cyclodextrin-PVP ternary systems

R. Ambrus, Z. Aigner, L. Catenacci, G. Bettinetti, P. Szabó-Révész, M. Sorrenti

Research output: Contribution to journalArticle

Abstract

In view of the poor aqueous solubility of nifluminic acid (NIF), the aim of this article was to improve its solubility and dissolution rate through the preparation of formulations based on hydroxypropyl β-cyclodextrin (HPβCD) and polyvinylpyrrolidone K25 (PVP K25), a combination of carriers which has been advantageously used for a similar purpose with various hydrophobic drugs. Ternary systems of NIF, HPβCD, and PVP K25 were prepared in different drug to CD to PVP ratios by physical mixing, kneading, microwave irradiation, and co-evaporation. Differential scanning calorimetry, thermogravimetric analysis, hot stage microscopy, Fourier transform infrared spectroscopy, and X-ray powder diffractometry were used to investigate the resulting solid-state interactions. The results showed that the solid state of the drug in the amorphous or crystalline ternary combinations influenced both the solubility and the dissolution rate of NIF.

Original languageEnglish
Pages (from-to)291-297
Number of pages7
JournalJournal of Thermal Analysis and Calorimetry
Volume104
Issue number1
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Cyclodextrins
Ternary systems
ternary systems
Povidone
dissolving
Dissolution
drugs
solubility
Solubility
acids
Acids
Pharmaceutical Preparations
solid state
Microwave irradiation
Powders
Thermogravimetric analysis
Differential scanning calorimetry
Microscopic examination
Evaporation
heat measurement

Keywords

  • Dissolution
  • FT-IR
  • Nifluminic acid
  • Thermal analysis
  • X-ray powder diffraction

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Condensed Matter Physics

Cite this

Physico-chemical characterization and dissolution properties of nifluminic acid-cyclodextrin-PVP ternary systems. / Ambrus, R.; Aigner, Z.; Catenacci, L.; Bettinetti, G.; Szabó-Révész, P.; Sorrenti, M.

In: Journal of Thermal Analysis and Calorimetry, Vol. 104, No. 1, 04.2011, p. 291-297.

Research output: Contribution to journalArticle

Ambrus, R. ; Aigner, Z. ; Catenacci, L. ; Bettinetti, G. ; Szabó-Révész, P. ; Sorrenti, M. / Physico-chemical characterization and dissolution properties of nifluminic acid-cyclodextrin-PVP ternary systems. In: Journal of Thermal Analysis and Calorimetry. 2011 ; Vol. 104, No. 1. pp. 291-297.
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