Physicochemical and analytical characteristics of amiodarone

M. Bonati, F. Gaspari, V. D'Aranno, E. Benfenati, P. Neyroz, F. Galletti, G. Tognoni

Research output: Contribution to journalArticlepeer-review

Abstract

Data are reported on the analytical and physicochemical characteristics of amiodarone, for use in identifying and/or assaying this antiarrhythmic agent. The drug is highly soluble in chloroform and poorly soluble in water. Its acid-base constant (pK(a) is 6.56, and its maximal lipid solubility range is from pH 3.5 to 5.5.

Original languageEnglish
Pages (from-to)829-831
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume73
Issue number6
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

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