Physiologic analysis of the myoclonus of alzheimer’s disease

D. E. Wilkins, M. Hallett, A. Berardelli, T. Walshe, N. Alvarez

Research output: Contribution to journalArticlepeer-review


Ten patients with clinically diagnosed Alzheimer’s disease, including three cases of trisomy 21 (Down’s syndrome), developed a chronic myoclonic disorder. The technique of jerk-locked averaging of EEG activity was used to analyze the myoclonus. Seven subjects demonstrated a focal, contralateral central, negative cerebral potential antecedent to the myoclonic jerks. This EEG event differs from that previously reported to be associated with the myoclonus of subacute spongiform encephalopathy (Creutzfeldt-Jakob disease).

Original languageEnglish
Pages (from-to)898-903
Number of pages6
Issue number7
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)


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