Physiologic correlates of tricuspid annular plane systolic excursion in 1168 healthy subjects

Francesco Ferrara, Lawrence G. Rudski, Olga Vriz, Luna Gargani, Jonathan Afilalo, Antonello D'Andrea, Michele D'Alto, Alberto M. Marra, Edvige Acri, Anna Agnese Stanziola, Stefano Ghio, Antonio Cittadini, Robert Naeije, Eduardo Bossone

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11 Citations (Scopus)

Abstract

Background TAPSE provides a simple, reproducible estimate of the longitudinal function of the right ventricle (RV). However, the normal limits and physiologic correlates of tricuspid annular plane systolic excursion (TAPSE) are not exactly known. The aim of this study was to explore the full spectrum of TAPSE values and determine the physiologic correlates of TAPSE. Methods and results From June 2007 to December 2013, 1168 healthy subjects [mean age 45.1 ± 16 years, range 16 to 92; 555 (47.5%) men] underwent comprehensive transthoracic echocardiography (TTE) as recommended by current guidelines. TAPSE values were higher in men than women (24.0 ± 3.5 vs 23.2 ± 3.0 mm, p value < 0.0001) but did not vary according to age. On multivariable linear regression analysis, cardiac output, RV basal and longitudinal dimensions were the only variables independently associated with TAPSE (β coefficient = 0.161, 0.116 and 0.115 respectively). On the other hand echocardiographically-derived systolic pulmonary artery pressure (SPAP), pulmonary vascular resistance and mitral E/e′ ratio were significantly higher in older subjects. Therefore a significant decrease of TAPSE/SPAP was detected in > 60 years old cohort (p = 0.0001). Conclusions Our large cohort of healthy subjects provides sex and age-based TAPSE and TAPSE/SPAP normal cut-offs. TAPSE was found to be higher in men but not influenced by age. It was mainly correlated with echo-Doppler indices reflecting pre-load as opposed to afterload. On the other hand a significant decrease of TAPSE/SPAP with older age was registered as a direct consequence of increased SPAP with aging.

Original languageEnglish
Pages (from-to)736-743
Number of pages8
JournalInternational Journal of Cardiology
Volume223
DOIs
Publication statusPublished - Nov 15 2016

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Healthy Volunteers
Heart Ventricles
Echocardiography
Guidelines

Keywords

  • Echocardiography
  • Healthy subjects
  • Pulmonary artery systolic pressure
  • Tricuspid annular plane systolic excursion

ASJC Scopus subject areas

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Ferrara, F., Rudski, L. G., Vriz, O., Gargani, L., Afilalo, J., D'Andrea, A., ... Bossone, E. (2016). Physiologic correlates of tricuspid annular plane systolic excursion in 1168 healthy subjects. International Journal of Cardiology, 223, 736-743. https://doi.org/10.1016/j.ijcard.2016.08.275

Physiologic correlates of tricuspid annular plane systolic excursion in 1168 healthy subjects. / Ferrara, Francesco; Rudski, Lawrence G.; Vriz, Olga; Gargani, Luna; Afilalo, Jonathan; D'Andrea, Antonello; D'Alto, Michele; Marra, Alberto M.; Acri, Edvige; Stanziola, Anna Agnese; Ghio, Stefano; Cittadini, Antonio; Naeije, Robert; Bossone, Eduardo.

In: International Journal of Cardiology, Vol. 223, 15.11.2016, p. 736-743.

Research output: Contribution to journalArticle

Ferrara, F, Rudski, LG, Vriz, O, Gargani, L, Afilalo, J, D'Andrea, A, D'Alto, M, Marra, AM, Acri, E, Stanziola, AA, Ghio, S, Cittadini, A, Naeije, R & Bossone, E 2016, 'Physiologic correlates of tricuspid annular plane systolic excursion in 1168 healthy subjects', International Journal of Cardiology, vol. 223, pp. 736-743. https://doi.org/10.1016/j.ijcard.2016.08.275
Ferrara, Francesco ; Rudski, Lawrence G. ; Vriz, Olga ; Gargani, Luna ; Afilalo, Jonathan ; D'Andrea, Antonello ; D'Alto, Michele ; Marra, Alberto M. ; Acri, Edvige ; Stanziola, Anna Agnese ; Ghio, Stefano ; Cittadini, Antonio ; Naeije, Robert ; Bossone, Eduardo. / Physiologic correlates of tricuspid annular plane systolic excursion in 1168 healthy subjects. In: International Journal of Cardiology. 2016 ; Vol. 223. pp. 736-743.
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abstract = "Background TAPSE provides a simple, reproducible estimate of the longitudinal function of the right ventricle (RV). However, the normal limits and physiologic correlates of tricuspid annular plane systolic excursion (TAPSE) are not exactly known. The aim of this study was to explore the full spectrum of TAPSE values and determine the physiologic correlates of TAPSE. Methods and results From June 2007 to December 2013, 1168 healthy subjects [mean age 45.1 ± 16 years, range 16 to 92; 555 (47.5{\%}) men] underwent comprehensive transthoracic echocardiography (TTE) as recommended by current guidelines. TAPSE values were higher in men than women (24.0 ± 3.5 vs 23.2 ± 3.0 mm, p value < 0.0001) but did not vary according to age. On multivariable linear regression analysis, cardiac output, RV basal and longitudinal dimensions were the only variables independently associated with TAPSE (β coefficient = 0.161, 0.116 and 0.115 respectively). On the other hand echocardiographically-derived systolic pulmonary artery pressure (SPAP), pulmonary vascular resistance and mitral E/e′ ratio were significantly higher in older subjects. Therefore a significant decrease of TAPSE/SPAP was detected in > 60 years old cohort (p = 0.0001). Conclusions Our large cohort of healthy subjects provides sex and age-based TAPSE and TAPSE/SPAP normal cut-offs. TAPSE was found to be higher in men but not influenced by age. It was mainly correlated with echo-Doppler indices reflecting pre-load as opposed to afterload. On the other hand a significant decrease of TAPSE/SPAP with older age was registered as a direct consequence of increased SPAP with aging.",
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AU - Ferrara, Francesco

AU - Rudski, Lawrence G.

AU - Vriz, Olga

AU - Gargani, Luna

AU - Afilalo, Jonathan

AU - D'Andrea, Antonello

AU - D'Alto, Michele

AU - Marra, Alberto M.

AU - Acri, Edvige

AU - Stanziola, Anna Agnese

AU - Ghio, Stefano

AU - Cittadini, Antonio

AU - Naeije, Robert

AU - Bossone, Eduardo

PY - 2016/11/15

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N2 - Background TAPSE provides a simple, reproducible estimate of the longitudinal function of the right ventricle (RV). However, the normal limits and physiologic correlates of tricuspid annular plane systolic excursion (TAPSE) are not exactly known. The aim of this study was to explore the full spectrum of TAPSE values and determine the physiologic correlates of TAPSE. Methods and results From June 2007 to December 2013, 1168 healthy subjects [mean age 45.1 ± 16 years, range 16 to 92; 555 (47.5%) men] underwent comprehensive transthoracic echocardiography (TTE) as recommended by current guidelines. TAPSE values were higher in men than women (24.0 ± 3.5 vs 23.2 ± 3.0 mm, p value < 0.0001) but did not vary according to age. On multivariable linear regression analysis, cardiac output, RV basal and longitudinal dimensions were the only variables independently associated with TAPSE (β coefficient = 0.161, 0.116 and 0.115 respectively). On the other hand echocardiographically-derived systolic pulmonary artery pressure (SPAP), pulmonary vascular resistance and mitral E/e′ ratio were significantly higher in older subjects. Therefore a significant decrease of TAPSE/SPAP was detected in > 60 years old cohort (p = 0.0001). Conclusions Our large cohort of healthy subjects provides sex and age-based TAPSE and TAPSE/SPAP normal cut-offs. TAPSE was found to be higher in men but not influenced by age. It was mainly correlated with echo-Doppler indices reflecting pre-load as opposed to afterload. On the other hand a significant decrease of TAPSE/SPAP with older age was registered as a direct consequence of increased SPAP with aging.

AB - Background TAPSE provides a simple, reproducible estimate of the longitudinal function of the right ventricle (RV). However, the normal limits and physiologic correlates of tricuspid annular plane systolic excursion (TAPSE) are not exactly known. The aim of this study was to explore the full spectrum of TAPSE values and determine the physiologic correlates of TAPSE. Methods and results From June 2007 to December 2013, 1168 healthy subjects [mean age 45.1 ± 16 years, range 16 to 92; 555 (47.5%) men] underwent comprehensive transthoracic echocardiography (TTE) as recommended by current guidelines. TAPSE values were higher in men than women (24.0 ± 3.5 vs 23.2 ± 3.0 mm, p value < 0.0001) but did not vary according to age. On multivariable linear regression analysis, cardiac output, RV basal and longitudinal dimensions were the only variables independently associated with TAPSE (β coefficient = 0.161, 0.116 and 0.115 respectively). On the other hand echocardiographically-derived systolic pulmonary artery pressure (SPAP), pulmonary vascular resistance and mitral E/e′ ratio were significantly higher in older subjects. Therefore a significant decrease of TAPSE/SPAP was detected in > 60 years old cohort (p = 0.0001). Conclusions Our large cohort of healthy subjects provides sex and age-based TAPSE and TAPSE/SPAP normal cut-offs. TAPSE was found to be higher in men but not influenced by age. It was mainly correlated with echo-Doppler indices reflecting pre-load as opposed to afterload. On the other hand a significant decrease of TAPSE/SPAP with older age was registered as a direct consequence of increased SPAP with aging.

KW - Echocardiography

KW - Healthy subjects

KW - Pulmonary artery systolic pressure

KW - Tricuspid annular plane systolic excursion

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