TY - JOUR
T1 - Physiologic role of coronary PGl2 and PGE2 in modulating coronary vascular response to sympathetic stimulation
AU - Neri Serneri, Gian Gastone
AU - Gensini, Gian Franco
AU - Abbate, Rosanna
AU - Castellani, Sergio
AU - Bonechi, Francesco
AU - Dagianti, Armando
AU - Arata, Luciano
AU - Fedele, Francesco
AU - Iacoboni, Carlo
AU - Prisco, Domenico
PY - 1990
Y1 - 1990
N2 - To investigate a physiologic role of coronary prostacyclin (PG12) and prostaglandin E2 (PGE2) 30 patients who were not affected by coronary heart dlsease were evaluated for coronary hemodynamics and coronary PGl2 and PGE2 production. Inhibition of coronary prostaglandin biosynthesis by ketoprofen (1 mg/kg) or aspirin (15 mg/kg) administered intravenously did not significantly change coronary hemodynamics in resting conditions. In all patients cold pressor tests induced significant increases in coronary blood flow (p2 (as 6-keto-PGF1α) and PGE2 formation was observed (p2 and PGE2 formation that was induced by cold pressor test and caused a paradoxical increase in coronary vascular resistance (ketoprofen: p
AB - To investigate a physiologic role of coronary prostacyclin (PG12) and prostaglandin E2 (PGE2) 30 patients who were not affected by coronary heart dlsease were evaluated for coronary hemodynamics and coronary PGl2 and PGE2 production. Inhibition of coronary prostaglandin biosynthesis by ketoprofen (1 mg/kg) or aspirin (15 mg/kg) administered intravenously did not significantly change coronary hemodynamics in resting conditions. In all patients cold pressor tests induced significant increases in coronary blood flow (p2 (as 6-keto-PGF1α) and PGE2 formation was observed (p2 and PGE2 formation that was induced by cold pressor test and caused a paradoxical increase in coronary vascular resistance (ketoprofen: p
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U2 - 10.1016/S0002-8703(05)80322-9
DO - 10.1016/S0002-8703(05)80322-9
M3 - Article
C2 - 2108576
AN - SCOPUS:0025287735
VL - 119
SP - 848
EP - 854
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 4
ER -