Physiologic role of coronary PGl2 and PGE2 in modulating coronary vascular response to sympathetic stimulation

Gian Gastone Neri Serneri, Gian Franco Gensini, Rosanna Abbate, Sergio Castellani, Francesco Bonechi, Armando Dagianti, Luciano Arata, Francesco Fedele, Carlo Iacoboni, Domenico Prisco

Research output: Contribution to journalArticlepeer-review

Abstract

To investigate a physiologic role of coronary prostacyclin (PG12) and prostaglandin E2 (PGE2) 30 patients who were not affected by coronary heart dlsease were evaluated for coronary hemodynamics and coronary PGl2 and PGE2 production. Inhibition of coronary prostaglandin biosynthesis by ketoprofen (1 mg/kg) or aspirin (15 mg/kg) administered intravenously did not significantly change coronary hemodynamics in resting conditions. In all patients cold pressor tests induced significant increases in coronary blood flow (p2 (as 6-keto-PGF) and PGE2 formation was observed (p2 and PGE2 formation that was induced by cold pressor test and caused a paradoxical increase in coronary vascular resistance (ketoprofen: p

Original languageEnglish
Pages (from-to)848-854
Number of pages7
JournalAmerican Heart Journal
Volume119
Issue number4
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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