Physiological aging impacts the hemispheric balances of resting state primary somatosensory activities

Carlo Cottone, Leo Tomasevic, Camillo Porcaro, Giancarlo Filligoi, Franca Tecchio

Research output: Contribution to journalArticlepeer-review

Abstract

To hone knowledge of sensorimotor cerebral organization changes with physiological aging, we focused on the primary somatosensory cortical area (S1). S1 neuronal pools (FS-S1) were identified by the functional source separation (FSS) algorithm applied to magnetoencephalographic recordings during median nerve stimulation. Age-dependence of FS-S1 was then studied at rest separately in the left and right hemispheres of 26 healthy, right-handed subjects between the ages of 24 and 95 years. The resting state FS-S1 spectral features changed with increasing age: (1) alpha activity slowed down; (2) total power increased only in the right hemisphere; (3) right>left interhemispheric asymmetry increased in the whole spectrum; (4) spectral entropy increased with age selectively in the left hemisphere. The present FSS-enriched electrophysiological procedure provided measures of resting state hand representation area sensitive to changes with age. Alterations were stronger in the right hemisphere. Relationships between resting state S1 activity and its responsiveness to external stimuli, revealed that the interhemispheric unbalances which emerged with age were conceivably due to an increased excitability within the right thalamocortical circuit impacting left versus right unbalances of spontaneous firing rates and of local inhibitory-excitatory networks.

Original languageEnglish
Pages (from-to)186-199
Number of pages14
JournalBrain Topography
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Functional source separation (FSS)
  • Interhemispheric asymmetries
  • Magnetoencephalography (MEG)
  • Median nerve stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Fingerprint Dive into the research topics of 'Physiological aging impacts the hemispheric balances of resting state primary somatosensory activities'. Together they form a unique fingerprint.

Cite this