Abstract
Apoptosis plays a crucial role in tissue homeostasis, development and many diseases. The relevance of Apaf1, the molecular core of apoptosome, has been underlined in mitochondria-dependent apoptosis, which according to a growing body of evidence, is involved in various pathologies where the equilibrium of life-and-death is dysregulated. The current chapter, besides providing an overview of the apoptotic machinery, will focus on knockout and knockin studies of key components of the apoptosis cascade, and analyses of the apoptosis dysregulation in many pathological conditions such as neurodegeneration, cancer, heart attack, autoimmune disease and virus infections.
| Original language | English |
|---|---|
| Title of host publication | Apoptosome: An Up-and-coming Therapeutical Tool |
| Publisher | Springer Netherlands |
| Pages | 1-26 |
| Number of pages | 26 |
| ISBN (Print) | 9789048134151, 9789048134144 |
| DOIs | |
| Publication status | Published - 2010 |
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Keywords
- Anti-apoptotic factors
- Apoptosis
- Apoptosis dysregulation
- Life-death decision
- Mitochondrial pathway
- Pro-apoptotic factors
ASJC Scopus subject areas
- Medicine(all)
Cite this
Physiological and pathological role of apoptosis. / Cavallucci, Virve; D'Amelio, Marcello.
Apoptosome: An Up-and-coming Therapeutical Tool. Springer Netherlands, 2010. p. 1-26.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Physiological and pathological role of apoptosis
AU - Cavallucci, Virve
AU - D'Amelio, Marcello
PY - 2010
Y1 - 2010
N2 - Apoptosis plays a crucial role in tissue homeostasis, development and many diseases. The relevance of Apaf1, the molecular core of apoptosome, has been underlined in mitochondria-dependent apoptosis, which according to a growing body of evidence, is involved in various pathologies where the equilibrium of life-and-death is dysregulated. The current chapter, besides providing an overview of the apoptotic machinery, will focus on knockout and knockin studies of key components of the apoptosis cascade, and analyses of the apoptosis dysregulation in many pathological conditions such as neurodegeneration, cancer, heart attack, autoimmune disease and virus infections.
AB - Apoptosis plays a crucial role in tissue homeostasis, development and many diseases. The relevance of Apaf1, the molecular core of apoptosome, has been underlined in mitochondria-dependent apoptosis, which according to a growing body of evidence, is involved in various pathologies where the equilibrium of life-and-death is dysregulated. The current chapter, besides providing an overview of the apoptotic machinery, will focus on knockout and knockin studies of key components of the apoptosis cascade, and analyses of the apoptosis dysregulation in many pathological conditions such as neurodegeneration, cancer, heart attack, autoimmune disease and virus infections.
KW - Anti-apoptotic factors
KW - Apoptosis
KW - Apoptosis dysregulation
KW - Life-death decision
KW - Mitochondrial pathway
KW - Pro-apoptotic factors
UR - http://www.scopus.com/inward/record.url?scp=84919638583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919638583&partnerID=8YFLogxK
U2 - 10.1007/978-90-481-3415-1-1
DO - 10.1007/978-90-481-3415-1-1
M3 - Chapter
AN - SCOPUS:84919638583
SN - 9789048134151
SN - 9789048134144
SP - 1
EP - 26
BT - Apoptosome: An Up-and-coming Therapeutical Tool
PB - Springer Netherlands
ER -