Physiological and pathological role of apoptosis

Virve Cavallucci; Marcello D'Amelio

doi:10.1007/978-90-481-3415-1-1

Physiological and pathological role of apoptosis

Virve Cavallucci, Marcello D'Amelio

Fondazione Santa Lucia

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Apoptosis plays a crucial role in tissue homeostasis, development and many diseases. The relevance of Apaf1, the molecular core of apoptosome, has been underlined in mitochondria-dependent apoptosis, which according to a growing body of evidence, is involved in various pathologies where the equilibrium of life-and-death is dysregulated. The current chapter, besides providing an overview of the apoptotic machinery, will focus on knockout and knockin studies of key components of the apoptosis cascade, and analyses of the apoptosis dysregulation in many pathological conditions such as neurodegeneration, cancer, heart attack, autoimmune disease and virus infections.

Original language	English
Title of host publication	Apoptosome: An Up-and-coming Therapeutical Tool
Publisher	Springer Netherlands
Pages	1-26
Number of pages	26
ISBN (Print)	9789048134151, 9789048134144
DOIs	https://doi.org/10.1007/978-90-481-3415-1-1
Publication status	Published - 2010

Keywords

Anti-apoptotic factors
Apoptosis
Apoptosis dysregulation
Life-death decision
Mitochondrial pathway
Pro-apoptotic factors

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-90-481-3415-1-1

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