Physiologically based pharmacokinetic modeling of perfluoroalkyl substances in the human body

Francesc Fàbrega, Vikas Kumar, Emilio Benfenati, Marta Schuhmacher, José L. Domingo, Martí Nadal

Research output: Contribution to journalArticlepeer-review

Abstract

Currently, there are limited data on the levels of perfluoroalkyl substances other than perfluorooctane sulfonic acid and perfluorooctanoic acid in the human body. Most of this information has been extracted from biological monitoring of plasma while the occurrence of perfluoroalkyl substances in other human tissues is rarely studied. The objective of the present study was to develop a physiologically based pharmacokinetic model to assess the concentration of perfluoroalkyl substances in human tissues, based on an existing model previously validated for perfluorooctane sulfonic acid and perfluorooctanoic acid. Experimental data on concentrations of perfluoroalkyl substances in human tissues from individuals in Tarragona County (Catalonia, Spain) were used to estimate the values of some distribution and elimination parameters needed for the simulation. No significant correlations were found between these parameters and the chain lengths. The model was finally validated for five perfluoroalkyl substances.

Original languageEnglish
Pages (from-to)814-827
Number of pages14
JournalToxicological and Environmental Chemistry
Volume97
Issue number6
DOIs
Publication statusPublished - Jul 3 2015

Keywords

  • elimination mechanisms
  • human body
  • model validation
  • PBPK modeling
  • perfluoroalkyl substances

ASJC Scopus subject areas

  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis
  • Pollution

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