Abstract
The endoplasmic reticulum (ER), the port of entry for proteins into the secretory pathway, is a multifunctional organelle emerging as a central integrator of numerous signalling pathways. The mechanisms that control proteostasis are integral part of this signalling network, providing cues for morphological and functional cell remodelling, proliferation, inflammation and cell death. The complexity of ER responses is exploited during physiological and pathological tissue development, cell differentiation and lifespan control. This essay outlines some of the mechanisms that link proteostasis within the early secretory compartment to signalling in development and disease.
Original language | English |
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Pages (from-to) | 520-525 |
Number of pages | 6 |
Journal | Seminars in Cell and Developmental Biology |
Volume | 21 |
Issue number | 5 |
DOIs | |
Publication status | Published - Jul 2010 |
Keywords
- B cell differentiation
- ERAD
- Protein condensation
- Proteotoxicity
- Russell bodies
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology