Physiology and pathology of proteostasis in the early secretory compartment

Tiziana Anelli, Roberto Sitia

Research output: Contribution to journalArticlepeer-review

Abstract

The endoplasmic reticulum (ER), the port of entry for proteins into the secretory pathway, is a multifunctional organelle emerging as a central integrator of numerous signalling pathways. The mechanisms that control proteostasis are integral part of this signalling network, providing cues for morphological and functional cell remodelling, proliferation, inflammation and cell death. The complexity of ER responses is exploited during physiological and pathological tissue development, cell differentiation and lifespan control. This essay outlines some of the mechanisms that link proteostasis within the early secretory compartment to signalling in development and disease.

Original languageEnglish
Pages (from-to)520-525
Number of pages6
JournalSeminars in Cell and Developmental Biology
Volume21
Issue number5
DOIs
Publication statusPublished - Jul 2010

Keywords

  • B cell differentiation
  • ERAD
  • Protein condensation
  • Proteotoxicity
  • Russell bodies

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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