Physiology and Pathophysiology of Coronary Circulation

Gaetano A. Lanza; Stefano Figliozzi; Rossella Parrinello

doi:10.1007/978-3-642-37078-6_58

Physiology and Pathophysiology of Coronary Circulation

Gaetano A. Lanza, Stefano Figliozzi, Rossella Parrinello

IRCCS Multimedica

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Coronary blood flow (CBF) is regulated in order to match oxygen requirements by myocardial cells and may increase up to fivefold, compared to baseline (coronary flow reserve), due to maximal myocardial oxygen demand, as a result of maximal dilatation of small resistance coronary arteries (arterioles and pre-arterioles). The regulation of CBF is mediated by metabolic, neural, circulating, and physical (vascular and extravascular) factors. An inadequate CBF for myocardial oxygen requirement results in myocardial ischemia. The pathophysiologic mechanisms responsible for myocardial ischemia (either in conditions of increased oxygen requirement or at rest) include atherosclerotic coronary flow-limiting stenosis, epicardial coronary artery spasm, coronary microvascular dysfunction and coronary thrombosis.

Original language	English
Title of host publication	PanVascular Medicine, Second Edition
Publisher	Springer Berlin Heidelberg
Pages	1789-1809
Number of pages	21
ISBN (Print)	9783642370786, 9783642370779
DOIs	https://doi.org/10.1007/978-3-642-37078-6_58
Publication status	Published - Jan 1 2015

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-3-642-37078-6_58

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Physiology and Pathophysiology of Coronary Circulation

Abstract

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