Physiology and Pathophysiology of Coronary Circulation

Gaetano A. Lanza; Stefano Figliozzi; Rossella Parrinello

doi:10.1007/978-3-642-37078-6_58

Physiology and Pathophysiology of Coronary Circulation

Gaetano A. Lanza, Stefano Figliozzi, Rossella Parrinello

IRCCS Multimedica

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Coronary blood flow (CBF) is regulated in order to match oxygen requirements by myocardial cells and may increase up to fivefold, compared to baseline (coronary flow reserve), due to maximal myocardial oxygen demand, as a result of maximal dilatation of small resistance coronary arteries (arterioles and pre-arterioles). The regulation of CBF is mediated by metabolic, neural, circulating, and physical (vascular and extravascular) factors. An inadequate CBF for myocardial oxygen requirement results in myocardial ischemia. The pathophysiologic mechanisms responsible for myocardial ischemia (either in conditions of increased oxygen requirement or at rest) include atherosclerotic coronary flow-limiting stenosis, epicardial coronary artery spasm, coronary microvascular dysfunction and coronary thrombosis.

Original language	English
Title of host publication	PanVascular Medicine, Second Edition
Publisher	Springer Berlin Heidelberg
Pages	1789-1809
Number of pages	21
ISBN (Print)	9783642370786, 9783642370779
DOIs	https://doi.org/10.1007/978-3-642-37078-6_58
Publication status	Published - Jan 1 2015

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/978-3-642-37078-6_58

Fingerprint Dive into the research topics of 'Physiology and Pathophysiology of Coronary Circulation'. Together they form a unique fingerprint.

Cite this

@inbook{2a6478132a2243dab00cff002d5365c9,

title = "Physiology and Pathophysiology of Coronary Circulation",

abstract = "Coronary blood flow (CBF) is regulated in order to match oxygen requirements by myocardial cells and may increase up to fivefold, compared to baseline (coronary flow reserve), due to maximal myocardial oxygen demand, as a result of maximal dilatation of small resistance coronary arteries (arterioles and pre-arterioles). The regulation of CBF is mediated by metabolic, neural, circulating, and physical (vascular and extravascular) factors. An inadequate CBF for myocardial oxygen requirement results in myocardial ischemia. The pathophysiologic mechanisms responsible for myocardial ischemia (either in conditions of increased oxygen requirement or at rest) include atherosclerotic coronary flow-limiting stenosis, epicardial coronary artery spasm, coronary microvascular dysfunction and coronary thrombosis.",

author = "Lanza, {Gaetano A.} and Stefano Figliozzi and Rossella Parrinello",

year = "2015",

month = jan,

day = "1",

doi = "10.1007/978-3-642-37078-6_58",

language = "English",

isbn = "9783642370786",

pages = "1789--1809",

booktitle = "PanVascular Medicine, Second Edition",

publisher = "Springer Berlin Heidelberg",

}

TY - CHAP

T1 - Physiology and Pathophysiology of Coronary Circulation

AU - Lanza, Gaetano A.

AU - Figliozzi, Stefano

AU - Parrinello, Rossella

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Coronary blood flow (CBF) is regulated in order to match oxygen requirements by myocardial cells and may increase up to fivefold, compared to baseline (coronary flow reserve), due to maximal myocardial oxygen demand, as a result of maximal dilatation of small resistance coronary arteries (arterioles and pre-arterioles). The regulation of CBF is mediated by metabolic, neural, circulating, and physical (vascular and extravascular) factors. An inadequate CBF for myocardial oxygen requirement results in myocardial ischemia. The pathophysiologic mechanisms responsible for myocardial ischemia (either in conditions of increased oxygen requirement or at rest) include atherosclerotic coronary flow-limiting stenosis, epicardial coronary artery spasm, coronary microvascular dysfunction and coronary thrombosis.

AB - Coronary blood flow (CBF) is regulated in order to match oxygen requirements by myocardial cells and may increase up to fivefold, compared to baseline (coronary flow reserve), due to maximal myocardial oxygen demand, as a result of maximal dilatation of small resistance coronary arteries (arterioles and pre-arterioles). The regulation of CBF is mediated by metabolic, neural, circulating, and physical (vascular and extravascular) factors. An inadequate CBF for myocardial oxygen requirement results in myocardial ischemia. The pathophysiologic mechanisms responsible for myocardial ischemia (either in conditions of increased oxygen requirement or at rest) include atherosclerotic coronary flow-limiting stenosis, epicardial coronary artery spasm, coronary microvascular dysfunction and coronary thrombosis.

UR - http://www.scopus.com/inward/record.url?scp=84957038599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957038599&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-37078-6_58

DO - 10.1007/978-3-642-37078-6_58

M3 - Chapter

AN - SCOPUS:84957038599

SN - 9783642370786

SN - 9783642370779

SP - 1789

EP - 1809

BT - PanVascular Medicine, Second Edition

PB - Springer Berlin Heidelberg

ER -