Physiology of immune system: Regulation of stem cell survival

Claudio Arra, Maria C. Turco, Morena D'avenia, Gaetano Torino, Aldo Giudice, Maria Pascale

Research output: Contribution to journalArticle

Abstract

The immune system is a complex defense mechanism, able to protect the body against pathogens. It consists of a network of cells, tissues, and organs that work together to protect the body. Leukocytes are key operatives of the immune system. Cells destined to become immune cells, like all blood cells, arise in your body's bone marrow from stem cells (HSC). A large body of evidence show the transcription factors play critical roles in the homeostasis of T cells, B cells, neutrophils and other non-lymphoid leneages. This review discusses the role of the Smek (Suppressor of mek null) gene, that acts in the stress response pathway of animals by binding to and enhancing the transcription of FoxO transcription factors. Furthermore, the review deals with tachykinins, involved in neurotransmission and immune/hematopoietic modulation. Both molecules, objects of recent patents, may have real therapeutic potential.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalRecent Patents on Endocrine, Metabolic and Immune Drug Discovery
Volume3
Issue number1
DOIs
Publication statusPublished - 2009

Fingerprint

Immune system
Physiology
Stem cells
Immune System
Cell Survival
Transcription Factors
Stem Cells
Cells
Tachykinins
T-cells
Pathogens
Transcription
Bone
Animals
Blood
Patents
Genes
Modulation
Tissue
Synaptic Transmission

Keywords

  • B cells
  • Haematopoietic stem cells (HSCs)
  • Immune system
  • Stress response
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Drug Discovery
  • Endocrinology, Diabetes and Metabolism
  • Biochemistry, medical

Cite this

Physiology of immune system : Regulation of stem cell survival. / Arra, Claudio; Turco, Maria C.; D'avenia, Morena; Torino, Gaetano; Giudice, Aldo; Pascale, Maria.

In: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery, Vol. 3, No. 1, 2009, p. 35-41.

Research output: Contribution to journalArticle

Arra, Claudio ; Turco, Maria C. ; D'avenia, Morena ; Torino, Gaetano ; Giudice, Aldo ; Pascale, Maria. / Physiology of immune system : Regulation of stem cell survival. In: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery. 2009 ; Vol. 3, No. 1. pp. 35-41.
@article{c35f622ba2774fe396f0328030f3ef5a,
title = "Physiology of immune system: Regulation of stem cell survival",
abstract = "The immune system is a complex defense mechanism, able to protect the body against pathogens. It consists of a network of cells, tissues, and organs that work together to protect the body. Leukocytes are key operatives of the immune system. Cells destined to become immune cells, like all blood cells, arise in your body's bone marrow from stem cells (HSC). A large body of evidence show the transcription factors play critical roles in the homeostasis of T cells, B cells, neutrophils and other non-lymphoid leneages. This review discusses the role of the Smek (Suppressor of mek null) gene, that acts in the stress response pathway of animals by binding to and enhancing the transcription of FoxO transcription factors. Furthermore, the review deals with tachykinins, involved in neurotransmission and immune/hematopoietic modulation. Both molecules, objects of recent patents, may have real therapeutic potential.",
keywords = "B cells, Haematopoietic stem cells (HSCs), Immune system, Stress response, T cells",
author = "Claudio Arra and Turco, {Maria C.} and Morena D'avenia and Gaetano Torino and Aldo Giudice and Maria Pascale",
year = "2009",
doi = "10.2174/187221409787002967",
language = "English",
volume = "3",
pages = "35--41",
journal = "Recent Patents on Endocrine, Metabolic and Immune Drug Discovery",
issn = "1872-2148",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - Physiology of immune system

T2 - Regulation of stem cell survival

AU - Arra, Claudio

AU - Turco, Maria C.

AU - D'avenia, Morena

AU - Torino, Gaetano

AU - Giudice, Aldo

AU - Pascale, Maria

PY - 2009

Y1 - 2009

N2 - The immune system is a complex defense mechanism, able to protect the body against pathogens. It consists of a network of cells, tissues, and organs that work together to protect the body. Leukocytes are key operatives of the immune system. Cells destined to become immune cells, like all blood cells, arise in your body's bone marrow from stem cells (HSC). A large body of evidence show the transcription factors play critical roles in the homeostasis of T cells, B cells, neutrophils and other non-lymphoid leneages. This review discusses the role of the Smek (Suppressor of mek null) gene, that acts in the stress response pathway of animals by binding to and enhancing the transcription of FoxO transcription factors. Furthermore, the review deals with tachykinins, involved in neurotransmission and immune/hematopoietic modulation. Both molecules, objects of recent patents, may have real therapeutic potential.

AB - The immune system is a complex defense mechanism, able to protect the body against pathogens. It consists of a network of cells, tissues, and organs that work together to protect the body. Leukocytes are key operatives of the immune system. Cells destined to become immune cells, like all blood cells, arise in your body's bone marrow from stem cells (HSC). A large body of evidence show the transcription factors play critical roles in the homeostasis of T cells, B cells, neutrophils and other non-lymphoid leneages. This review discusses the role of the Smek (Suppressor of mek null) gene, that acts in the stress response pathway of animals by binding to and enhancing the transcription of FoxO transcription factors. Furthermore, the review deals with tachykinins, involved in neurotransmission and immune/hematopoietic modulation. Both molecules, objects of recent patents, may have real therapeutic potential.

KW - B cells

KW - Haematopoietic stem cells (HSCs)

KW - Immune system

KW - Stress response

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=70349221536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349221536&partnerID=8YFLogxK

U2 - 10.2174/187221409787002967

DO - 10.2174/187221409787002967

M3 - Article

AN - SCOPUS:70349221536

VL - 3

SP - 35

EP - 41

JO - Recent Patents on Endocrine, Metabolic and Immune Drug Discovery

JF - Recent Patents on Endocrine, Metabolic and Immune Drug Discovery

SN - 1872-2148

IS - 1

ER -