Basi fisiopatologiche dell'encefalopatia minima del cirrotico

Translated title of the contribution: Physiopathologic basis of the hepatic encephalopathy

Michele Giambra, Giovanna Cappelo, Tiziana Brusca, Ornella Ferrara, Maria Elisa Campagna, Sveva Corsale, Anna Maria Abbene, Angelo Maria Patti, Alessandro Parrino, Giuseppe Montalto

Research output: Contribution to journalArticle

Abstract

Hepatic encephalopathy is a neuropsychiatric syndrome characterized by a wide spectrum of mental and motor disturbances. It may show as an overt encephalopathy, when it is clinically well defined, or as a minimal hepatic encephalopathy (MHE), which refers to a neuropsychiatric condition not revealed by routine clinical tests, but using specific psychometric and neurophysiological techniques. As a matter of fact MHE involves the fine cognitive functions that influence the essential daily activities of, such as the ability to drive and some visuospatial ability, pertaining, calculating and handling activities. The physiopathological bases of MHE depend on the changes occurring in the intestinal lumen, following the haemodynamic alterations of the splanchnic circulation that favourishes the bacterial growth and increases the ammonia load from the intestine. From a prognostic point of view, the presence of MHE is associated to a decrease of the quality of life and the ability to work with an increased mortality, at least in patients with a high Child-Pugh score. Moreover, MHE represents a risk factor for the development of an overt encephalopathy. The treatment of MHE improves the quality of life of cirrhotic patients, but the long term therapy points out serious concerns about compliance and tolerance. The main therapeutic aims are: to induce a reduction of ammonia load and toxins coming from the intestine, using cathartic drugs and the management of the potential triggering factors which lead to MHE.

Original languageItalian
Pages (from-to)127-133
Number of pages7
JournalActa Medica Mediterranea
Volume22
Issue number3
Publication statusPublished - 2006

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Hepatic Encephalopathy
Aptitude
Brain Diseases
Ammonia
Intestines
Quality of Life
Splanchnic Circulation
Cathartics
Psychometrics
Cognition
Compliance
Therapeutics
Hemodynamics
Mortality
Growth
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Giambra, M., Cappelo, G., Brusca, T., Ferrara, O., Campagna, M. E., Corsale, S., ... Montalto, G. (2006). Basi fisiopatologiche dell'encefalopatia minima del cirrotico. Acta Medica Mediterranea, 22(3), 127-133.

Basi fisiopatologiche dell'encefalopatia minima del cirrotico. / Giambra, Michele; Cappelo, Giovanna; Brusca, Tiziana; Ferrara, Ornella; Campagna, Maria Elisa; Corsale, Sveva; Abbene, Anna Maria; Patti, Angelo Maria; Parrino, Alessandro; Montalto, Giuseppe.

In: Acta Medica Mediterranea, Vol. 22, No. 3, 2006, p. 127-133.

Research output: Contribution to journalArticle

Giambra, M, Cappelo, G, Brusca, T, Ferrara, O, Campagna, ME, Corsale, S, Abbene, AM, Patti, AM, Parrino, A & Montalto, G 2006, 'Basi fisiopatologiche dell'encefalopatia minima del cirrotico', Acta Medica Mediterranea, vol. 22, no. 3, pp. 127-133.
Giambra M, Cappelo G, Brusca T, Ferrara O, Campagna ME, Corsale S et al. Basi fisiopatologiche dell'encefalopatia minima del cirrotico. Acta Medica Mediterranea. 2006;22(3):127-133.
Giambra, Michele ; Cappelo, Giovanna ; Brusca, Tiziana ; Ferrara, Ornella ; Campagna, Maria Elisa ; Corsale, Sveva ; Abbene, Anna Maria ; Patti, Angelo Maria ; Parrino, Alessandro ; Montalto, Giuseppe. / Basi fisiopatologiche dell'encefalopatia minima del cirrotico. In: Acta Medica Mediterranea. 2006 ; Vol. 22, No. 3. pp. 127-133.
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