Abstract
Background: Falling levels of estrogen is the major provocative factor in migraine associated with menstruation. Objective: We assessed the efficacy of the combination of two phyto-oestrogens, as perimenstrual, prophylactic treatment of menstrual migraine and tested their effect on cerebral haemodynamic. Subjects and Methods: Women with a history of menstrual migraine (ie, attacks occurring exclusively on day 1 ± 2 days of menstruation and at no other time of the cycle) were included in the study. Eleven women fulfilling the inclusion criteria underwent to a 3-month cyclic treatment with 56 mg of genisteine and 20 mg of diadzeine per day. Transcranial doppler evaluation (TCD) was performed at baseline and after treatment. Results: Among the ten women who completed the study the average number of days with migraine during the baseline period decreased significantly after 3 months of therapy (P <0.005). There were no major side-effects. Therapy did not affect cerebral blood flow velocities. Conclusions: Phyto-oestrogens appear to be an effective treatment in menstrual migraine prophylaxis. This effect seems to be unrelated to cerebral hemodynamic. Placebo-controlled trials on larger number of patients are necessary to confirm our findings.
Original language | English |
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Pages (from-to) | 137-140 |
Number of pages | 4 |
Journal | Clinical Neuropharmacology |
Volume | 27 |
Issue number | 3 |
DOIs | |
Publication status | Published - May 2004 |
Keywords
- Cerebral hemodynamic
- Menstrual migraine
- Phyto-oestrogens
- Prophylaxis
ASJC Scopus subject areas
- Pharmacology (medical)
- Clinical Neurology
- Neuroscience(all)
- Pharmacology, Toxicology and Pharmaceutics(all)