Abstract
Background: Cerebrovascular disease caused by atherosclerosis affecting cerebral and pre-cerebral arteries is one of the leading causes of morbidity and mortality in high-income countries. Medications of botanical origin are often characterized by good tolerability and are suitable for long-term treatment. Therefore, phytotherapy provides an interesting possibility for developing new therapies for the prevention of atherosclerosis and its complications that could be used at preclinical stages of the disease. Objective: We reviewed the current literature studying the potential of various plant-based medications for prevention and treatment of early cerebral ischemia induced by atherosclerosis. Methods: Literature search was performed in PubMed, Scopus, and Cochrane library to find trials on phytotherapy in cerebrovascular prevention and treatment. Results: The present review covers the recent data on the prevention of cerebral ischemia with natural preparations and demonstrates the effect of anti-atherosclerotic therapy on the dynamics of minor neurological changes. Conclusion: Phytotherapy appears to have a great potential for cerebrovascular disease prevention, combining good safety profiles with pleiotropic effects on different mechanisms atherosclerosis-related cerebral ischemia development.
| Original language | English |
|---|---|
| Pages (from-to) | 408-413 |
| Number of pages | 6 |
| Journal | Current Drug Metabolism |
| Volume | 19 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
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Keywords
- Atherosclerosis
- Carotid IMT
- Cerebral ischemia
- Cerebrovascular disease
- Natural preparation
- Phytotherapy
ASJC Scopus subject areas
- Pharmacology
- Clinical Biochemistry
Cite this
Phytotherapy for the prevention of atherosclerosis-associated early cerebral ischemia. / Kirichenko, Tatiana V.; Myasoedova, Veronika A.; Sobenin, Igor A.; Orekhov, Alexander N.
In: Current Drug Metabolism, Vol. 19, No. 5, 01.01.2018, p. 408-413.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Phytotherapy for the prevention of atherosclerosis-associated early cerebral ischemia
AU - Kirichenko, Tatiana V.
AU - Myasoedova, Veronika A.
AU - Sobenin, Igor A.
AU - Orekhov, Alexander N.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Cerebrovascular disease caused by atherosclerosis affecting cerebral and pre-cerebral arteries is one of the leading causes of morbidity and mortality in high-income countries. Medications of botanical origin are often characterized by good tolerability and are suitable for long-term treatment. Therefore, phytotherapy provides an interesting possibility for developing new therapies for the prevention of atherosclerosis and its complications that could be used at preclinical stages of the disease. Objective: We reviewed the current literature studying the potential of various plant-based medications for prevention and treatment of early cerebral ischemia induced by atherosclerosis. Methods: Literature search was performed in PubMed, Scopus, and Cochrane library to find trials on phytotherapy in cerebrovascular prevention and treatment. Results: The present review covers the recent data on the prevention of cerebral ischemia with natural preparations and demonstrates the effect of anti-atherosclerotic therapy on the dynamics of minor neurological changes. Conclusion: Phytotherapy appears to have a great potential for cerebrovascular disease prevention, combining good safety profiles with pleiotropic effects on different mechanisms atherosclerosis-related cerebral ischemia development.
AB - Background: Cerebrovascular disease caused by atherosclerosis affecting cerebral and pre-cerebral arteries is one of the leading causes of morbidity and mortality in high-income countries. Medications of botanical origin are often characterized by good tolerability and are suitable for long-term treatment. Therefore, phytotherapy provides an interesting possibility for developing new therapies for the prevention of atherosclerosis and its complications that could be used at preclinical stages of the disease. Objective: We reviewed the current literature studying the potential of various plant-based medications for prevention and treatment of early cerebral ischemia induced by atherosclerosis. Methods: Literature search was performed in PubMed, Scopus, and Cochrane library to find trials on phytotherapy in cerebrovascular prevention and treatment. Results: The present review covers the recent data on the prevention of cerebral ischemia with natural preparations and demonstrates the effect of anti-atherosclerotic therapy on the dynamics of minor neurological changes. Conclusion: Phytotherapy appears to have a great potential for cerebrovascular disease prevention, combining good safety profiles with pleiotropic effects on different mechanisms atherosclerosis-related cerebral ischemia development.
KW - Atherosclerosis
KW - Carotid IMT
KW - Cerebral ischemia
KW - Cerebrovascular disease
KW - Natural preparation
KW - Phytotherapy
UR - http://www.scopus.com/inward/record.url?scp=85048964931&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048964931&partnerID=8YFLogxK
U2 - 10.2174/1389200219666180305151601
DO - 10.2174/1389200219666180305151601
M3 - Review article
C2 - 29512455
AN - SCOPUS:85048964931
VL - 19
SP - 408
EP - 413
JO - Current Drug Metabolism
JF - Current Drug Metabolism
SN - 1389-2002
IS - 5
ER -