PI3K/Akt/mTOR signaling in medullary thyroid cancer: a promising molecular target for cancer therapy

Gloria Irene Manfredi, Alessandra Dicitore, Germano Gaudenzi, Michele Caraglia, Luca Persani, Giovanni Vitale

Research output: Contribution to journalArticle

Abstract

The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is a central hub for the regulation of cell proliferation, apoptosis, cell cycle, metabolism, and angiogenesis. Several studies have recently suggested that the PI3K/Akt/mTOR signaling pathway is implicated in the pathogenesis and progression of neuroendocrine tumors. Medullary thyroid cancer (MTC) is a neuroendocrine tumor developing from the C cells of the thyroid. Mutations in the RET proto-oncogene are involved in the pathogenesis of several forms of MTC. The deregulation of the PI3K/Akt/mTOR pathway seems to contribute to the tumorigenic activity of RET proto-oncogene mutations. Targeting this pathway through specific inhibitors at simple or multiple sites may represent an attractive potential therapeutic approach for patients with advanced MTCs. The aim of this review is to examine the role of the PI3K/Akt/mTOR pathway in the development and progression of MTC and the new therapeutic options that target this signaling pathway.

Original languageEnglish
Pages (from-to)363-370
Number of pages8
JournalEndocrine
Volume48
Issue number2
DOIs
Publication statusPublished - 2015

Keywords

  • Medullary thyroid cancer
  • mTOR
  • PI3K/Akt
  • Targeted therapy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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