Pidotimod: A reappraisal

Piersandro Riboldi, M. Gerosa, P. L. Meroni

Research output: Contribution to journalArticlepeer-review


Pidotimod (Polimod ®) is a synthetic dipeptide molecule with biological and immunological activity on both the adaptive and the innate immune responses. In vitro studies, both from animal and human specimens, have documented a good activity on innate and adaptive immune responses and have been confirmed by in vivo studies. These activities have been applied in clinical studies demonstrating the efficacy of pidotimod in reducing the rate of recurrent infections of the upper respiratory and urinary tracts in children. The same results were obtained in recurrent respiratory tract infections in adults. Interestingly, these effects are more evident in the setting of immune defects such as senescence, Down's syndrome, and cancer.

Original languageEnglish
Pages (from-to)255-262
Number of pages8
JournalInternational Journal of Immunopathology and Pharmacology
Issue number2
Publication statusPublished - Apr 2009


  • Immunodeficiency
  • Innate immunity
  • Pidotimod
  • Recurrent infections

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology


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