Piecemeal degranulation in human tumour pheochromocytes

Enrico Crivellato, Nicoletta Finato, Domenico Ribatti, Carlo Alberto Beltrami

Research output: Contribution to journalArticle

Abstract

Piecemeal degranulation (PMD) has been recognized in two cases of human pheochromocytoma from the adrenal medulla, which were studied by transmission electron microscopy. Tumour pheochromocytes presented a highly characteristic cytoplasmic admixture of normal resting granules, swollen granules with eroded matrices and enlarged empty containers. Chromaffin granules that appeared to be normal and altered granules maintained their individual structure, and did not fuse with each other or with the plasma membrane. In accordance with the currently accepted model for granule discharge during PMD, electron-dense or clear vesicles 30-150 nm in diameter were seen either attached to the surface of chromaffin granules and the plasma membrane or free in the cytosol. This is the first description of PMD in human adrenal chromaffin cells and, in addition, is the first report of PMD in tumour secretory cells. These findings add further to the concept that PMD may have a broader spectrum of expression than hitherto recognized.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalJournal of Anatomy
Volume206
Issue number1
DOIs
Publication statusPublished - Jan 2005

Fingerprint

Chromaffin Granules
tumor
granules
chromaffin granules
Cell Membrane
membrane
plasma
Chromaffin Cells
neoplasms
Adrenal Medulla
Pheochromocytoma
vesicle
Transmission Electron Microscopy
Cytosol
transmission electron microscopy
Neoplasms
plasma membrane
Electrons
chromaffin cells
adrenal medulla

Keywords

  • Cell secretion
  • Chromaffin granules
  • Pheochromocytoma
  • Piecemeal degranulation
  • Transmission electron microscopy

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Cite this

Crivellato, E., Finato, N., Ribatti, D., & Beltrami, C. A. (2005). Piecemeal degranulation in human tumour pheochromocytes. Journal of Anatomy, 206(1), 47-53. https://doi.org/10.1111/j.0021-8782.2005.00365.x

Piecemeal degranulation in human tumour pheochromocytes. / Crivellato, Enrico; Finato, Nicoletta; Ribatti, Domenico; Beltrami, Carlo Alberto.

In: Journal of Anatomy, Vol. 206, No. 1, 01.2005, p. 47-53.

Research output: Contribution to journalArticle

Crivellato, E, Finato, N, Ribatti, D & Beltrami, CA 2005, 'Piecemeal degranulation in human tumour pheochromocytes', Journal of Anatomy, vol. 206, no. 1, pp. 47-53. https://doi.org/10.1111/j.0021-8782.2005.00365.x
Crivellato, Enrico ; Finato, Nicoletta ; Ribatti, Domenico ; Beltrami, Carlo Alberto. / Piecemeal degranulation in human tumour pheochromocytes. In: Journal of Anatomy. 2005 ; Vol. 206, No. 1. pp. 47-53.
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