PIK3CA mutations and BRCA1 expression in breast cancer: Potential biomarkers for chemoresistance

Mariacarmela Santarpia, Giuseppe Altavilla, Mireia Margeli, Beatriz Cirauqui, Mario Mesiti, Vittorio Cavallari, Jose Luis Ramirez, Maria Sanchez-Ronco, Libero Santarpia, Miquel Taron, Rafael Rosell

Research output: Contribution to journalArticle

Abstract

Mutations in PIK3CA and alterations of BRCA1 expression are common in breast cancer and have been correlated with altered sensitivity to taxanes in human cancer cell lines and with outcome of patients. We assessed mutations in the three hotspots of PIK3CA (E542K, E545K and H1047R) and intratumoral BRCA1 mRNA expression by quantitative RT-PCR in 61 breast cancer patients. Mutations of PIK3CA were found in 17 (27.9%) and did not correlate with BRCA1 transcript levels. Correlation with clinical and pathological features identified a significant association of mutations with older patients (P = 0.03). Higher BRCA1 mRNA expression was significantly correlated with advanced disease (P = 0.01) and ERBB2 overexpression (P = 0.02). These findings may help to identify a subgroup of patients who will likely benefit from chemotherapy regimens containing microtubule-disrupting agents.

Original languageEnglish
Pages (from-to)1044-1051
Number of pages8
JournalCancer Investigation
Volume26
Issue number10
DOIs
Publication statusPublished - Dec 2008

Keywords

  • BRCA1 expression
  • Breast cancer
  • Chemoresistance
  • PIK3CA mutations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Santarpia, M., Altavilla, G., Margeli, M., Cirauqui, B., Mesiti, M., Cavallari, V., Ramirez, J. L., Sanchez-Ronco, M., Santarpia, L., Taron, M., & Rosell, R. (2008). PIK3CA mutations and BRCA1 expression in breast cancer: Potential biomarkers for chemoresistance. Cancer Investigation, 26(10), 1044-1051. https://doi.org/10.1080/07357900802112701